Is Acetyl Tributyl Citrate safe in cosmetics?
Acetyl Tributyl Citrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Acetyl Tributyl Citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester, 2-(Acetyloxy)-1,2,3-tributyloate-1,2,3-propanetricarboxylic acid, Acetylcitric acid, tributyl ester, BRN 2303316, Caswell No. 005AB (+6 more)
INCI: ACETYL TRIBUTYL CITRATE
Acetyl Tributyl Citrate (CAS 77-90-7) is a cosmetic cosmetic ingredient functioning as Plasticizer; solvent; film-former. Reported NOAEL 250 mg/kg bw/day in rat (COSMOS_DB); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 77-90-7 →
Auto-generated CPSR Part A draft with source citations
Function
Plasticizer; solvent; film-former
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tributyl 2-acetyloxypropane-1,2,3-tricarboxylate
InChIKey
QZCLKYGREBVARF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction; CIR (2002, reaffirmed 2023) safe as used up to 8.9% in nail products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tributyl Citrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Acetyl Tributyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (3)
JECFA Number
630
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ACETYL TRIBUTYL CITRATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TRIBUTYL ACETYLCITRATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Deodorizer
Film former
Flavouring and nutrient
Fragrance
Lubricating agent
Plasticizer
Processing aids not otherwise specified
Solvent
Stabilizing agent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tributyl Citrate.
Regulatory Flags
nail-products-primary
phthalate-free-plasticizer
film-former
cir-safe-reaffirmed-2023
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acetyl Tributyl Citrate by CAS number or substance name.
Studies
3
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester
2-(Acetyloxy)-1,2,3-tributyloate-1,2,3-propanetricarboxylic acid
Acetylcitric acid, tributyl ester
BRN 2303316
Caswell No. 005AB
EINECS 201-067-0
FEMA No. 3080
Tributyl acetyl citrate
Tributyl 2-(acetyloxy)-1,2,3-propanetricarboxylate
UNII-0ZBX0N59RZ
Acetyltributylcitrate
Chemical Function
Plasticizer
Deodorizer
Fragrance
Film former
Flavouring and nutrient
Solvent
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe
consumer_product; Europe
consumer_product; Europe
Arts and crafts/Office supplies - fabric treatment and dye; detected
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe; plastic_additive
Frequently Asked Questions
Is Acetyl Tributyl Citrate allowed in the EU?
Acetyl Tributyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tributyl Citrate do in cosmetics?
Acetyl Tributyl Citrate functions as: Plasticizer; solvent; film-former. It is classified as a cosmetic ingredient in our database. CAS number: 77-90-7.
What is the NOAEL for Acetyl Tributyl Citrate?
The NOAEL (No Observed Adverse Effect Level) for Acetyl Tributyl Citrate is 250 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Acetyl Tributyl Citrate used outside cosmetics?
Acetyl Tributyl Citrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acetyl Tributyl Citrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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