Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acetyl Tributyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | cat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2495 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1780 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2623 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Phthalate-free plasticizer permitted in EU and US; CIR concluded safe up to 8.9% in nail products and 7% in eye-contact products; not genotoxic or reproductive toxicant at cosmetic exposures.
Regulatory Flags
Frequently Asked Questions
Is Acetyl Tributyl Citrate safe in cosmetics?
Phthalate-free plasticizer permitted in EU and US; CIR concluded safe up to 8.9% in nail products and 7% in eye-contact products; not genotoxic or reproductive toxicant at cosmetic exposures. The EU classifies Acetyl Tributyl Citrate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Acetyl Tributyl Citrate allowed in the EU?
Acetyl Tributyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tributyl Citrate do in cosmetics?
Acetyl Tributyl Citrate functions as: Plasticizer; solvent; film-former. It is classified as a cosmetic ingredient in our database. CAS number: 77-90-7.
What is the Margin of Safety for Acetyl Tributyl Citrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acetyl Tributyl Citrate?
The NOAEL (No Observed Adverse Effect Level) for Acetyl Tributyl Citrate is 10000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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