NOAEL Data REACH Registered Cosmetic Ingredient

Triethyl citrate

Also known as: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl ester, BRN 1801199, EINECS 201-070-7, FEMA No. 3083, Triethyl 2-hydroxy-1,2,3-propanetricarboxylate (+3 more)

CAS 77-93-0

Triethyl citrate (CAS 77-93-0) is a chemical substance. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Triethyl Citrate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

Triethyl citrate

CAS Number

77-93-0

Molecular Formula

C12H20O7

InChI Key

DOOTYTYQINUNNV-UHFFFAOYSA-N

Monoisotopic Mass

276.120903

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl esterBRN 1801199EINECS 201-070-7FEMA No. 3083Triethyl 2-hydroxy-1,2,3-propanetricarboxylateTriaethylcitratTriethylester kyseliny citronoveUNII-8Z96QXD6UM

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and respiratory tract.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceSolventPlasticizerDeodorizerpH regulating agentAntioxidantFlavouring and nutrientNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
detected; MN Chemical Screening; surface_water	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
consumer_product	P&G	Proctor & Gamble
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; MN Chemical Screening; surface_water	National Parks Service	State of Minnesota

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 12 of 12 studies

Value	Unit	Endpoint	Route	Species	Source
<=20	mg/kg	ADI	oral	Human	WHO/JECFA
=73.5	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
8Z96QXD6UM	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1.350e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
14.68	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
0	unitless	Model Score	-	-	NTP ICE endocrine
226	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
280	mg/kg bw/day	NOAEL	oral	cat	COSMOS DB
284	mg/kg bw/day	NOAEL	oral	dog	COSMOS DB
4000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization

Showing 12 of 12 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Triethyl citrate	201-070-7	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.3-1%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed TRIETHYL CITRATE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E1505 — ADI: 0-20 mg/kg bw (1984) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Triethyl citrate?

Triethyl citrate has 12 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Triethyl citrate?

Triethyl citrate appears on 11 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, Europe; plastic_additive, and 8 more. Source: EPA CPDat.

Is Triethyl citrate used in cosmetics?

Yes, Triethyl citrate is also indexed as a cosmetic ingredient under the name Triethyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Triethyl citrate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Triethyl citrate used outside industrial chemicals?

Triethyl citrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.