What is the NOAEL for Triethyl citrate?
Triethyl citrate has 15 NOAEL studies in the database. The lowest reported value is 20 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triethyl citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl ester, BRN 1801199, EINECS 201-070-7, FEMA No. 3083, Triethyl 2-hydroxy-1,2,3-propanetricarboxylate (+3 more)
CAS 77-93-0
Triethyl citrate (CAS 77-93-0) is a chemical substance. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
17
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Triethyl citrate
CAS Number
77-93-0
DTXSID
DTXSID0040701
Molecular Formula
C12H20O7
InChI Key
DOOTYTYQINUNNV-UHFFFAOYSA-N
Monoisotopic Mass
276.120903
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl esterBRN 1801199EINECS 201-070-7FEMA No. 3083Triethyl 2-hydroxy-1,2,3-propanetricarboxylateTriaethylcitratTriethylester kyseliny citronoveUNII-8Z96QXD6UM
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceSolventPlasticizerDeodorizerpH regulating agentAntioxidantFlavouring and nutrientNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
17 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=20 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =73.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8Z96QXD6UM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Z96QXD6UM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Z96QXD6UM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Z96QXD6UM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 14.6809 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 226 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 280 | mg/kg bw/day | NOAEL | oral | cat | COSMOS_DB |
| 284 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triethyl citrate | 201-070-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.3-1%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TRIETHYL CITRATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E1505 — ADI: 0-20 mg/kg bw (1984) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Triethyl citrate?
Triethyl citrate appears on 11 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, Europe; plastic_additive, and 8 more. Source: EPA CPDat.
Is Triethyl citrate used in cosmetics?
Yes, Triethyl citrate is also indexed as a cosmetic ingredient under the name Triethyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triethyl citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Triethyl citrate used outside industrial chemicals?
Triethyl citrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.