Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Triethyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 280 mg/kg bw/day | oral | cat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 284 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 226 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 4000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 284 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Antimicrobial deodorant active with enzymatic metabolic disruption mechanism. Bacteria consume triethyl citrate, triggering bacterial esterase-mediated hydrolysis to release citric acid and ethanol, both of which inhibit the bacterial Krebs cycle and disrupt energy metabolism without broad-spectrum microbiome disruption. Operates optimally at pH 5 with minimal sensitization potential and excellent tolerability. GRAS food-grade compound suitable for microbiome-friendly deodorant positioning.
Regulatory Flags
Frequently Asked Questions
Is Triethyl Citrate safe in cosmetics?
Antimicrobial deodorant active with enzymatic metabolic disruption mechanism. Bacteria consume triethyl citrate, triggering bacterial esterase-mediated hydrolysis to release citric acid and ethanol, both of which inhibit the bacterial Krebs cycle and disrupt energy metabolism without broad-spectrum microbiome disruption. Operates optimally at pH 5 with minimal sensitization potential and excellent tolerability. GRAS food-grade compound suitable for microbiome-friendly deodorant positioning. The EU classifies Triethyl Citrate as "permitted". Safety rating: EXCELLENT. 6 toxicological study endpoint(s) are available in our database.
Is Triethyl Citrate allowed in the EU?
Triethyl Citrate EU regulatory status: permitted. Maximum allowed concentration: 0.3-1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Triethyl Citrate do in cosmetics?
Triethyl Citrate functions as: deodorant active; antimicrobial; pH regulator; fragrance fixative; plasticizer. It is classified as a Active Ingredient in our database. CAS number: 77-93-0.
What is the Margin of Safety for Triethyl Citrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triethyl Citrate?
The NOAEL (No Observed Adverse Effect Level) for Triethyl Citrate is 4000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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