What is the NOAEL for 1-Phenoxy-2-propanol?
1-Phenoxy-2-propanol has 9 NOAEL studies in the database. The lowest reported value is 25.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Phenoxy-2-propanol
Also known as: 2-Propanol, 1-phenoxy-, beta-Phenoxyisopropanol, Propylene phenoxetol, Phenoxyisopropanol, (+/-)-1-Phenoxy-2-propanol (+2 more)
CAS 770-35-4
1-Phenoxy-2-propanol (CAS 770-35-4) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
1-Phenoxy-2-propanol is classified GHS Danger (H319, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
1-Phenoxy-2-propanol
CAS Number
770-35-4
DTXSID
DTXSID9027312
Molecular Formula
C9H12O2
InChI Key
IBLKWZIFZMJLFL-UHFFFAOYSA-N
Monoisotopic Mass
152.08373
Synonyms
2-Propanol, 1-phenoxy-beta-PhenoxyisopropanolPropylene phenoxetolPhenoxyisopropanol(+/-)-1-Phenoxy-2-propanolEINECS 212-222-7UNII-87CZY0NY1A
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
51 records
SolventPreservativeSurfactant (surface active agent)Film formerCoalescing agentSolubility enhancer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care | European Commission | CosIng |
| Europe; nondetect; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =25.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 87CZY0NY1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87CZY0NY1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87CZY0NY1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87CZY0NY1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2830 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3730 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-phenoxypropan-2-ol | 212-222-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1327532
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 1-Phenoxy-2-propanol?
1-Phenoxy-2-propanol appears on 7 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care, Europe; nondetect; Personal care - sexual wellness, and 4 more. Source: EPA CPDat.
Is 1-Phenoxy-2-propanol used in cosmetics?
Yes, 1-Phenoxy-2-propanol is also indexed as a cosmetic ingredient under the name Phenoxyisopropanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Phenoxy-2-propanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Phenoxy-2-propanol have different safety status in cosmetics vs industrial chemicals?
1-Phenoxy-2-propanol is classified GHS Danger (H319, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 1%.
Is 1-Phenoxy-2-propanol used outside industrial chemicals?
1-Phenoxy-2-propanol also appears in cosmetics, pharmaceutical databases.