Is Phenoxyisopropanol safe in cosmetics?
Phenoxyisopropanol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Phenoxyisopropanol
Also known as: 2-Propanol, 1-phenoxy-, beta-Phenoxyisopropanol, Propylene phenoxetol, (+/-)-1-Phenoxy-2-propanol, EINECS 212-222-7 (+1 more)
INCI: PHENOXYISOPROPANOL
Phenoxyisopropanol (CAS 770-35-4) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 770-35-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Phenoxyisopropanol is classified GHS Danger (H319, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 1%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative (antimicrobial)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-phenoxypropan-2-ol
InChIKey
IBLKWZIFZMJLFL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
1%
US US Status
permitted
US Notes
Not specifically restricted by FDA; permitted as a cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenoxyisopropanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Phenoxyisopropanol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Product type: Only for rinse-off products
Max: 1.0%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Preservative. Max: 1.0% (rinse-off only). Leave-on prohibited
SA Saudi SFDA (III - Restricted)
Product type: Rinse-off products Not to be used in oral products. Max: 0.02.
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max 1,0%
India: Restricted · max 0.02
India: Permitted Preservative · max 0.01
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 1.0 | rinse-off products only |
| BR | restricted | 2 | Rinse-off products only; prohibited in oral hygiene products |
| BR | permitted_preservative | 1 | Prohibited in leave-on products |
| ASEAN | permitted_preservative | 1.0% | Rinse-off products only |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
... Potential for severe eye irritation but is not significantly irritating to skin after acute exposure.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Coalescing agent
Film former
Preservative
Solubility enhancer
Solvent
Surfactant (surface active agent)
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Phenoxyisopropanol.
Regulatory Flags
preservative
eu_cosing_listed
Known Synonyms
2-Propanol, 1-phenoxy-
beta-Phenoxyisopropanol
Propylene phenoxetol
(+/-)-1-Phenoxy-2-propanol
EINECS 212-222-7
UNII-87CZY0NY1A
Chemical Function
Solvent
Preservative
Surfactant (surface active agent)
Film former
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care
Europe; nondetect; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
Europe; Personal care - sexual wellness
detected; Personal care; Southeast Asia
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1327532
Frequently Asked Questions
Is Phenoxyisopropanol allowed in the EU?
Phenoxyisopropanol EU regulatory status: restricted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenoxyisopropanol do in cosmetics?
Phenoxyisopropanol functions as: Preservative (antimicrobial). It is classified as a cosmetic ingredient in our database. CAS number: 770-35-4.
Is Phenoxyisopropanol used outside cosmetics?
Phenoxyisopropanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Phenoxyisopropanol have different safety status in cosmetics vs industrial chemicals?
Phenoxyisopropanol is classified GHS Danger (H319, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 1%.
Compliance Tools
Check Phenoxyisopropanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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