Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Phenoxyisopropanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOEL | ca.35 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 1000 ppm | oral | rat | oral | REACH |
| NOEL | 82 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Restricted to rinse-off products at maximum 1% concentration in the EU; prohibited in leave-on products under EU Regulation (EC) 1223/2009. Permitted in the US with no concentration restrictions, creating regulatory divergence for export formulations.
Regulatory Flags
Frequently Asked Questions
Is Phenoxyisopropanol safe in cosmetics?
Restricted to rinse-off products at maximum 1% concentration in the EU; prohibited in leave-on products under EU Regulation (EC) 1223/2009. Permitted in the US with no concentration restrictions, creating regulatory divergence for export formulations. The EU classifies Phenoxyisopropanol as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Phenoxyisopropanol allowed in the EU?
Phenoxyisopropanol EU regulatory status: restricted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenoxyisopropanol do in cosmetics?
Phenoxyisopropanol functions as: Preservative (antimicrobial). It is classified as a cosmetic ingredient in our database. CAS number: 770-35-4.
What is the Margin of Safety for Phenoxyisopropanol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenoxyisopropanol?
The NOAEL (No Observed Adverse Effect Level) for Phenoxyisopropanol is 1000 mg/kg bw/day based on a dermal study via dermal route in code:3484. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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