What is the NOAEL for Tetrasodium pyrophosphate?
Tetrasodium pyrophosphate has 21 NOAEL studies in the database. The lowest reported value is 17.63 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetrasodium pyrophosphate
Also known as: Caswell No. 847, EINECS 231-767-1, EPA Pesticide Chemical Code 076405, NSC 56751, Sodium diphosphate, anhydrous (+7 more)
CAS 7722-88-5
Tetrasodium pyrophosphate (CAS 7722-88-5) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for TETRASODIUM PYROPHOSPHATE →
Cross-Vertical Regulatory Divergence
Tetrasodium pyrophosphate is classified GHS Danger (H302, H315, H318, H319, H335, H312, H332, H413) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Tetrasodium pyrophosphate
CAS Number
7722-88-5
DTXSID
DTXSID9042465
Molecular Formula
4Na.H4O7P2
InChI Key
FQENQNTWSFEDLI-UHFFFAOYSA-J
Monoisotopic Mass
269.902304
Synonyms
Caswell No. 847EINECS 231-767-1EPA Pesticide Chemical Code 076405NSC 56751Sodium diphosphate, anhydrousSodium pyrophosphate, tetrabasicTetrasodium pyrophosphate, anhydrousUNII-O352864B8ZNatrium pyrophosphatPyrophosphoric acid tetrasodium saltSodium pyrophosphateTSPP
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of dust and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PharmaceuticalpH regulating agentChelating agentAnti-caking agentCorrosion inhibitorEmulsifierThickening agentDispersing agentLubricating agentOxidizing agentHumectantDrierProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.63 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =44.08 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| O352864B8Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O352864B8Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O352864B8Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O352864B8Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >7940 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| 130 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| >130 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 138 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >138 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1600 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =250 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =49 | mg P/kg-day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrasodium pyrophosphate | 231-767-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Chelators
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM PYROPHOSPHATE
ChEMBL Phase
-1
Adverse Events
6
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E450iii — ADI: 40 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tetrasodium pyrophosphate?
Tetrasodium pyrophosphate appears on 9 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 6 more. Source: EPA CPDat.
Is Tetrasodium pyrophosphate used in cosmetics?
Yes, Tetrasodium pyrophosphate is also indexed as a cosmetic ingredient under the name TETRASODIUM PYROPHOSPHATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetrasodium pyrophosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Tetrasodium pyrophosphate have different safety status in cosmetics vs industrial chemicals?
Tetrasodium pyrophosphate is classified GHS Danger (H302, H315, H318, H319, H335, H312, H332, H413) in the chemicals database but is allowed in EU cosmetics.
Is Tetrasodium pyrophosphate used outside industrial chemicals?
Tetrasodium pyrophosphate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.