Good Cosmetic Ingredient NOAEL Data GHS Classified

TETRASODIUM PYROPHOSPHATE

CAS Number
7722-88-5
Function
Anticaking, Buffering, Chelating, Oral Care
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status restricted
US Notes CIR: SQ - IJT 40(S1):34-85

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for TETRASODIUM PYROPHOSPHATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 138 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 130 mg/kg bw/day oral mouse Developmental COSMOS_DB
dose_tested 1600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 200 mg/kg bw/day oral rat Chronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of dust and by ingestion.

Expert Verdict

TETRASODIUM PYROPHOSPHATE is listed in the EU CosIng database with functions: Anticaking, Buffering, Chelating, Oral Care It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment eu_children_restricted epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is TETRASODIUM PYROPHOSPHATE safe in cosmetics?

TETRASODIUM PYROPHOSPHATE is listed in the EU CosIng database with functions: Anticaking, Buffering, Chelating, Oral Care It is permitted in the EU without specific restrictions. The EU classifies TETRASODIUM PYROPHOSPHATE as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is TETRASODIUM PYROPHOSPHATE allowed in the EU?

TETRASODIUM PYROPHOSPHATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does TETRASODIUM PYROPHOSPHATE do in cosmetics?

TETRASODIUM PYROPHOSPHATE functions as: Anticaking, Buffering, Chelating, Oral Care. It is classified as a cosmetic ingredient in our database. CAS number: 7722-88-5.

What is the NOAEL for TETRASODIUM PYROPHOSPHATE?

The NOAEL (No Observed Adverse Effect Level) for TETRASODIUM PYROPHOSPHATE is 1600 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check TETRASODIUM PYROPHOSPHATE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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