Is TETRASODIUM PYROPHOSPHATE safe in cosmetics?
TETRASODIUM PYROPHOSPHATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 5 toxicological study endpoint(s) are available in our database.
TETRASODIUM PYROPHOSPHATE
Also known as: Caswell No. 847, EINECS 231-767-1, EPA Pesticide Chemical Code 076405, NSC 56751, Sodium diphosphate, anhydrous (+7 more)
TETRASODIUM PYROPHOSPHATE (CAS 7722-88-5) is a cosmetic cosmetic ingredient functioning as Anticaking, Buffering, Chelating, Oral Care. NOAEL 130 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7722-88-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
TETRASODIUM PYROPHOSPHATE is classified GHS Danger (H302, H315, H318, H319, H335, H312, H332, H413) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Anticaking, Buffering, Chelating, Oral Care
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tetrasodium;phosphonato phosphate
InChIKey
FQENQNTWSFEDLI-UHFFFAOYSA-J
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 40(S1):34-85
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
5 study endpoints found for TETRASODIUM PYROPHOSPHATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 130 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 138 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of dust and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for TETRASODIUM PYROPHOSPHATE across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | >2 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | >300 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | ~1624 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =1825 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =2150 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =3770 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | ~1624 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
oral_care
{"cas_number": "7722-88-5", "ingredient_class": "anti_tartar", "function_primary": "Anti-tartar agent", "function_secondary": "Stain prevention", "fluoride_content_ppm_if_applicable": "0", "whitening_mechanism": "Chelates metal ions that cause staining", "stain_removal_efficacy": "Low to moderate (prevention)", "tooth_shade_improvement_Vita_units": "0-1", "anti_tartar_mechanism": "Chelates calcium…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1140
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
SODIUM PYROPHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Chelating agent
Corrosion inhibitor
Dispersing agent
Drier
Emulsifier
Humectant
Lubricating agent
Oxidizing agent
Pharmaceutical
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for TETRASODIUM PYROPHOSPHATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
eu_children_restricted
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TETRASODIUM PYROPHOSPHATE by CAS number or substance name.
Studies
8
Lowest NOAEL
130 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Caswell No. 847
EINECS 231-767-1
EPA Pesticide Chemical Code 076405
NSC 56751
Sodium diphosphate, anhydrous
Sodium pyrophosphate, tetrabasic
Tetrasodium pyrophosphate, anhydrous
UNII-O352864B8Z
Natrium pyrophosphat
Pyrophosphoric acid tetrasodium salt
Sodium pyrophosphate
TSPP
Chemical Function
Pharmaceutical
pH regulating agent
Chelating agent
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Indirect additives food contact (10/2018)
children; Europe; Personal care
children; Europe; Personal care - dental care - toothpaste
animal_products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM PYROPHOSPHATE
ChEMBL ID
CHEMBL450079
Max Phase
-1
Adverse Event Associations
6
Frequently Asked Questions
Is TETRASODIUM PYROPHOSPHATE allowed in the EU?
TETRASODIUM PYROPHOSPHATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TETRASODIUM PYROPHOSPHATE do in cosmetics?
TETRASODIUM PYROPHOSPHATE functions as: Anticaking, Buffering, Chelating, Oral Care. It is classified as a cosmetic ingredient in our database. CAS number: 7722-88-5.
What is the NOAEL for TETRASODIUM PYROPHOSPHATE?
The NOAEL (No Observed Adverse Effect Level) for TETRASODIUM PYROPHOSPHATE is 130 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is TETRASODIUM PYROPHOSPHATE used outside cosmetics?
TETRASODIUM PYROPHOSPHATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does TETRASODIUM PYROPHOSPHATE have different safety status in cosmetics vs industrial chemicals?
TETRASODIUM PYROPHOSPHATE is classified GHS Danger (H302, H315, H318, H319, H335, H312, H332, H413) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check TETRASODIUM PYROPHOSPHATE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-DICARBOXYPYRIDINE
Good
Same category
Chelating
CURCUBITURILS
Good
Same category
Absorbent, Chelating, Emulsion Stabil...
DISODIUM GLUCARATE/GLUCONATE/GLUCURONATE/GLYCOLATE/KETOGLUCONATE/OXALATE/TARTRATE/TARTRONATE
Good
Same category
Chelating
OCTYL POLYSTYRENE OXIDE/PEG-10 COPOLYMER
Good
Same category
Antistatic, Chelating
PENTETIC ACID
Good
Same category
Chelating
PHOSPHONOBUTANETRICARBOXYLIC ACID
Good
Same category
Anticorrosive, Buffering, Chelating
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Ammonium Phosphate
Good
Chemical family
Buffering, pH Adjuster, Corrosion Inh...
Hydrogen Peroxide
Moderate
Chemical family
oxidizing agent; hair bleach; melanin...
TETRACARBOXYMETHYL NARINGENINCHALCONE
Good
Browse nearby
Skin Conditioning
Is TETRASODIUM PYROPHOSPHATE in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for TETRASODIUM PYROPHOSPHATE in your formulation.