What is the GHS hazard classification for Monomenthyl succinate?
Monomenthyl succinate (CAS 77341-67-4) is classified under EU CLP Annex VI as Eye Dam. 1 with signal word Danger. Hazard statements: H318. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Monomenthyl succinate
Also known as: Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester, Monomenthyl succinate, (-)-, Butanedioic acid, mono(5-methyl-2-(1-methylethyl)cyclohexyl) ester, (1R-(1alpha,2beta,5alpha))-, (1R-(1-alpha,2beta,5alpha))-Mono(5-methyl-2-(1-methylethyl)cyclohexyl)butanedioate, Mono(5-methyl-2-(1-methylethyl)cyclohexyl) butanedioate, (1R-(1alpha,2beta,5alpha))- (+1 more)
CAS 77341-67-4
Monomenthyl succinate (CAS 77341-67-4) is a chemical substance with GHS signal word Danger; key hazard signal: H318. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Monomenthyl succinate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Monomenthyl succinate
CAS Number
77341-67-4
DTXSID
DTXSID10228071
Molecular Formula
C14H24O4
InChI Key
BLILOGGUTRWFNI-GRYCIOLGSA-N
Monoisotopic Mass
256.167459
Synonyms
Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] esterMonomenthyl succinate, (-)-Butanedioic acid, mono(5-methyl-2-(1-methylethyl)cyclohexyl) ester, (1R-(1alpha,2beta,5alpha))-(1R-(1-alpha,2beta,5alpha))-Mono(5-methyl-2-(1-methylethyl)cyclohexyl)butanedioateMono(5-methyl-2-(1-methylethyl)cyclohexyl) butanedioate, (1R-(1alpha,2beta,5alpha))-UNII-85MHF9Y3DI
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Dam. 1 | H318 | GHS05 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
AstringentFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 85MHF9Y3DI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 85MHF9Y3DI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 85MHF9Y3DI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 85MHF9Y3DI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (1R-(1-alpha,2beta,5alpha))-Mono(5-methyl-2-(1-methylethyl)cyclohexyl)butanedioate | 426-890-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What is the NOAEL for Monomenthyl succinate?
Monomenthyl succinate has 4 NOAEL studies in the database. The lowest reported value is 85MHF9Y3DI UNII. Source: openFDA substances.
What regulatory lists include Monomenthyl succinate?
Monomenthyl succinate appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Monomenthyl succinate used in cosmetics?
Yes, Monomenthyl succinate is also indexed as a cosmetic ingredient under the name Menthyl Succinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Monomenthyl succinate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Monomenthyl succinate have different safety status in cosmetics vs industrial chemicals?
Monomenthyl succinate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Monomenthyl succinate used outside industrial chemicals?
Monomenthyl succinate also appears in cosmetics, food safety databases.