Is Menthyl Succinate safe in cosmetics?
Menthyl Succinate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Menthyl Succinate
Also known as: Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester, Monomenthyl succinate, (-)-, Butanedioic acid, mono(5-methyl-2-(1-methylethyl)cyclohexyl) ester, (1R-(1alpha,2beta,5alpha))-, (1R-(1-alpha,2beta,5alpha))-Mono(5-methyl-2-(1-methylethyl)cyclohexyl)butanedioate, Mono(5-methyl-2-(1-methylethyl)cyclohexyl) butanedioate, (1R-(1alpha,2beta,5alpha))- (+1 more)
INCI: MENTHYL SUCCINATE
Menthyl Succinate (CAS 77341-67-4) is a cosmetic cosmetic ingredient functioning as Astringent (contracts/tightens skin), fragrance functional (excipient of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 77341-67-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Menthyl Succinate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Astringent (contracts/tightens skin), fragrance functional (excipient of perfume/flavour compositions)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-4-oxobutanoic acid
InChIKey
BLILOGGUTRWFNI-GRYCIOLGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; no prohibitions or restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Menthyl Succinate.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Eye Dam. 1
Hazard Statements
- H318 Causes serious eye damage
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
447
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
MONO-MENTHYL SUCCINATE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/111 | FAS 42-JECFA 51/381
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Astringent
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Menthyl Succinate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester
Monomenthyl succinate, (-)-
Butanedioic acid, mono(5-methyl-2-(1-methylethyl)cyclohexyl) ester, (1R-(1alpha,2beta,5alpha))-
(1R-(1-alpha,2beta,5alpha))-Mono(5-methyl-2-(1-methylethyl)cyclohexyl)butanedioate
Mono(5-methyl-2-(1-methylethyl)cyclohexyl) butanedioate, (1R-(1alpha,2beta,5alpha))-
UNII-85MHF9Y3DI
Chemical Function
Astringent
Flavouring and nutrient
Fragrance
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Menthyl Succinate allowed in the EU?
Menthyl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthyl Succinate do in cosmetics?
Menthyl Succinate functions as: Astringent (contracts/tightens skin), fragrance functional (excipient of perfume/flavour compositions). It is classified as a cosmetic ingredient in our database. CAS number: 77341-67-4.
Is Menthyl Succinate used outside cosmetics?
Menthyl Succinate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Menthyl Succinate have different safety status in cosmetics vs industrial chemicals?
Menthyl Succinate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Menthyl Succinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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