What is the NOAEL for Potassium nitrate?
Potassium nitrate has 26 NOAEL studies in the database. The lowest reported value is 3.7 mg/kg bw/day in Consumers. Source: EFSA.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Potassium nitrate
Also known as: Nitric acid potassium salt, Nitric acid potassium salt (1:1), KNO3, Caswell No. 697, EINECS 231-818-8 (+12 more)
CAS 7757-79-1
Potassium nitrate (CAS 7757-79-1) is a chemical substance. Key regulatory status: REACH registered, 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.
Cross-Vertical Regulatory Divergence
Potassium nitrate is classified GHS Danger (H272, H315, H319, H335, H361, H370, H372, H303) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
26
SOURCE
Chemical inventory jurisdictions
Regulatory lists
26
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Potassium nitrate
CAS Number
7757-79-1
DTXSID
DTXSID4029692
Molecular Formula
K.NO3
InChI Key
FGIUAXJPYTZDNR-UHFFFAOYSA-N
Monoisotopic Mass
100.951524
Synonyms
Nitric acid potassium saltNitric acid potassium salt (1:1)KNO3Caswell No. 697EINECS 231-818-8EPA Pesticide Chemical Code 076103Kalii nitrasNSC 57632Potassium nitrate(DOT)VickniteUNII-RU45X2JN0ZNiter
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
PharmaceuticalHumectantNo specific technical functionBiocideFlavouring and nutrientDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.7 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =3.7 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| RU45X2JN0Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU45X2JN0Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU45X2JN0Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU45X2JN0Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1130 | mg/kg bw/day | LOAEL | oral | Guinea Pig | ToxValDB DOE Wildlife Benchmarks |
| =120 | mg/L | LOEL | oral | Rat | ToxValDB ECOTOX |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 14 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 15 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 26 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 29 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 50 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| =180 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 200 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 225 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =280 | mg/kg bw/day | NOAEL | oral | Hamster | ECHA |
| =400 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =507 | mg/kg bw/day | NOAEL | oral | Guinea Pig | ToxValDB DOE Wildlife Benchmarks |
| 737 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| >=1500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 8190 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS DB |
Showing 26 of 26 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Potassium nitrate | 231-818-8 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Potassium nitrate | N511 - Nitrate compounds (water dissociable; aqueous solution only) | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
POTASSIUM NITRATE
ChEMBL Phase
4
Adverse Events
19
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Potassium nitrate?
Potassium nitrate appears on 6 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 3 more. Source: EPA CPDat.
Is Potassium nitrate used in cosmetics?
Yes, Potassium nitrate is also indexed as a cosmetic ingredient under the name Potassium Nitrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Potassium nitrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Potassium nitrate have different safety status in cosmetics vs industrial chemicals?
Potassium nitrate is classified GHS Danger (H272, H315, H319, H335, H361, H370, H372, H303) in the chemicals database but is allowed in EU cosmetics.
Is Potassium nitrate used outside industrial chemicals?
Potassium nitrate also appears in cosmetics, pharmaceutical, cannabis databases.