Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Potassium Nitrate

CAS Number
7757-79-1
Function
Biocide; Dye; Flavouring and nutrient; Humectant; No specific technical function; Pharmaceutical
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Potassium Nitrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral rabbit Short Term Toxicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Reproductive-developmental COSMOS_DB
NOAEL 737 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 8190 mg/kg bw/day oral guinea pig Reproductive COSMOS_DB
NOAEL 50 mg/kg bw/day oral mouse Special Toxicology Study COSMOS_DB
NOAEL 50 mg/kg bw/day oral mouse Special Toxicology Study COSMOS_DB
NOAEL 50 mg/kg bw/day oral mouse Special Toxicology Study COSMOS_DB
NOAEL 225 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 14 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 250 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

⚠️
Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Potassium Nitrate safe in cosmetics?

Potassium Nitrate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.

Is Potassium Nitrate allowed in the EU?

Potassium Nitrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Nitrate do in cosmetics?

Potassium Nitrate functions as: Biocide; Dye; Flavouring and nutrient; Humectant; No specific technical function; Pharmaceutical. It is classified as a cosmetic ingredient in our database. CAS number: 7757-79-1.

What is the Margin of Safety for Potassium Nitrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Nitrate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Nitrate is 200 mg/kg bw/day based on a Short Term Toxicity study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Potassium Nitrate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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