What is the NOAEL for Sodium (E,E)-2,4-hexadienoate?
Sodium (E,E)-2,4-hexadienoate has 7 NOAEL studies in the database. The lowest reported value is 25 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Cosmetic Ingredient
Sodium (E,E)-2,4-hexadienoate
Also known as: Sodium α-trans-γ-trans-sorbate, 2,4-Hexadienoic acid, sodium salt (1:1), (2E,4E)-, 2,4-Hexadienoic acid, sodium salt, (2E,4E)-, 2,4-Hexadienoic acid, sodium salt, (E,E)-, (E,E)-2,4-Hexadienoic acid sodium salt (+13 more)
CAS 7757-81-5
Sodium (E,E)-2,4-hexadienoate (CAS 7757-81-5) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Sodium (E,E)-2,4-hexadienoate
CAS Number
7757-81-5
DTXSID
DTXSID8047181
Molecular Formula
C6H8O2.Na
InChI Key
LROWVYNUWKVTCU-STWYSWDKSA-M
Synonyms
Sodium α-trans-γ-trans-sorbate2,4-Hexadienoic acid, sodium salt (1:1), (2E,4E)-2,4-Hexadienoic acid, sodium salt, (2E,4E)-2,4-Hexadienoic acid, sodium salt, (E,E)-(E,E)-2,4-Hexadienoic acid sodium saltsodium (E,E)-hexa-2,4-dienoate(E,E)-hexa-2,4-dienoate de sodiumNatrium-(E,E)-hexa-2,4-dienoat(E,E)-hexa-2,4-dienoato de sodiosodium hexa-2,4-dienoateEC 231-819-3EINECS 231-819-3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
PreservativeBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| TGW6Q2CCVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TGW6Q2CCVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TGW6Q2CCVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TGW6Q2CCVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =7160 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.6%
Category
Preservative
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E201 — ADI: 25 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Sodium (E,E)-2,4-hexadienoate?
Sodium (E,E)-2,4-hexadienoate appears on 2 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Sodium (E,E)-2,4-hexadienoate used in cosmetics?
Yes, Sodium (E,E)-2,4-hexadienoate is also indexed as a cosmetic ingredient under the name Sodium Sorbate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium (E,E)-2,4-hexadienoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium (E,E)-2,4-hexadienoate used outside industrial chemicals?
Sodium (E,E)-2,4-hexadienoate also appears in cosmetics, food safety databases.