What is the NOAEL for Dipotassium hydrogenorthophosphate?
Dipotassium hydrogenorthophosphate has 10 NOAEL studies in the database. The lowest reported value is 19.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dipotassium hydrogenorthophosphate
Also known as: K2HPO4, Dipotassium monohydrogen phosphate, Dipotassium-O-phosphate, EINECS 231-834-5, UNII-CI71S98N1Z (+5 more)
CAS 7758-11-4
Dipotassium hydrogenorthophosphate (CAS 7758-11-4) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dipotassium hydrogenorthophosphate is classified GHS Danger (H315, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Dipotassium hydrogenorthophosphate
CAS Number
7758-11-4
DTXSID
DTXSID8035506
Molecular Formula
2K.H3O4P
InChI Key
ZPWVASYFFYYZEW-UHFFFAOYSA-L
Monoisotopic Mass
175.904309
Synonyms
K2HPO4Dipotassium monohydrogen phosphateDipotassium-O-phosphateEINECS 231-834-5UNII-CI71S98N1ZHydrogen dipotassium phosphatePotassium phosphate (dibasic)Potassium phosphate, dibasicdipotassium hydrogenphosphatepotassium dibasic phosphate trihydrate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
38 records
pH regulating agentCorrosion inhibitorFlavouring and nutrientSoil amendmentsPharmaceuticalOtherChelating agentEmulsifierThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =19.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| CI71S98N1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CI71S98N1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CI71S98N1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CI71S98N1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| 650 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =49 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dipotassium hydrogenorthophosphate | 231-834-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
buffering agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
POTASSIUM PHOSPHATE, DIBASIC
ChEMBL Phase
4
Adverse Events
20
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E450iv — ADI: 40 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dipotassium hydrogenorthophosphate?
Dipotassium hydrogenorthophosphate appears on 5 regulatory/inventory lists including animal_products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 2 more. Source: EPA CPDat.
Is Dipotassium hydrogenorthophosphate used in cosmetics?
Yes, Dipotassium hydrogenorthophosphate is also indexed as a cosmetic ingredient under the name Dipotassium Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dipotassium hydrogenorthophosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dipotassium hydrogenorthophosphate have different safety status in cosmetics vs industrial chemicals?
Dipotassium hydrogenorthophosphate is classified GHS Danger (H315, H318) in the chemicals database but is allowed in EU cosmetics.
Is Dipotassium hydrogenorthophosphate used outside industrial chemicals?
Dipotassium hydrogenorthophosphate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.