Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dipotassium Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 650 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 650 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Dipotassium phosphate (CAS 7758-11-4, EC 231-834-5) is permitted in the EU without restriction under Regulation (EC) No 1223/2009 and in the US based on CIR 2021 safety assessment and FDA GRAS status as a food additive. Functions as a buffering and anticorrosive agent with negligible dermal absorption and no sensitization signals.
Regulatory Flags
Frequently Asked Questions
Is Dipotassium Phosphate safe in cosmetics?
Dipotassium phosphate (CAS 7758-11-4, EC 231-834-5) is permitted in the EU without restriction under Regulation (EC) No 1223/2009 and in the US based on CIR 2021 safety assessment and FDA GRAS status as a food additive. Functions as a buffering and anticorrosive agent with negligible dermal absorption and no sensitization signals. The EU classifies Dipotassium Phosphate as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is Dipotassium Phosphate allowed in the EU?
Dipotassium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipotassium Phosphate do in cosmetics?
Dipotassium Phosphate functions as: Buffering agent, anticorrosive, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 7758-11-4.
What is the Margin of Safety for Dipotassium Phosphate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dipotassium Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Dipotassium Phosphate is 650 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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