What is the NOAEL for Sodium pyrophosphate?
Sodium pyrophosphate has 16 NOAEL studies in the database. The lowest reported value is 17.63 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium pyrophosphate
Also known as: SODIUM ACID PYROPHOSPHATE, EINECS 231-835-0, Dinatriumpyrophosphat, UNII-H5WVD9LZUD
CAS 7758-16-9
Sodium pyrophosphate (CAS 7758-16-9) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Sodium pyrophosphate
CAS Number
7758-16-9
DTXSID
DTXSID7044261
Molecular Formula
2Na.H4O7P2
InChI Key
GYQBBRRVRKFJRG-UHFFFAOYSA-L
Monoisotopic Mass
223.922765
Synonyms
SODIUM ACID PYROPHOSPHATEEINECS 231-835-0DinatriumpyrophosphatUNII-H5WVD9LZUD
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
36 records
pH regulating agentChelating agentCorrosion inhibitorDispersing agentFlavouring and nutrientTanning agents not otherwise specifiedOxidizing agentChemical reaction regulatorOtherEmulsifierProcessing aids not otherwise specifiedDyeLeavening agentFillerFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.63 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =44.08 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H5WVD9LZUD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5WVD9LZUD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5WVD9LZUD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5WVD9LZUD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >0.58 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >7940 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| 128 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| 166 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 169 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 335 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =49 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium dihydrogenpyrophosphate | 231-835-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Chelating Agents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM ACID PYROPHOSPHATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E450i — ADI: 40 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sodium pyrophosphate?
Sodium pyrophosphate appears on 6 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), animal_products, inert_ingredient; Pesticides, and 3 more. Source: EPA CPDat.
Is Sodium pyrophosphate used in cosmetics?
Yes, Sodium pyrophosphate is also indexed as a cosmetic ingredient under the name Disodium Pyrophosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium pyrophosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium pyrophosphate used outside industrial chemicals?
Sodium pyrophosphate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.