Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Disodium Pyrophosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 335 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 169 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 166 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 128 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 335 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 169 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 166 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| dose_tested | 128 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| LOEL | 0.6 other | oral | rat | oral | REACH |
| LOEL | 514 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
CIR-reviewed as part of phosphoric acid salts group and found safe; FDA GRAS status for food provides additional confidence; inorganic salt with low expected dermal penetration; GHS flagged for eye irritation.
Regulatory Flags
Frequently Asked Questions
Is Disodium Pyrophosphate safe in cosmetics?
CIR-reviewed as part of phosphoric acid salts group and found safe; FDA GRAS status for food provides additional confidence; inorganic salt with low expected dermal penetration; GHS flagged for eye irritation. The EU classifies Disodium Pyrophosphate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Disodium Pyrophosphate allowed in the EU?
Disodium Pyrophosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Pyrophosphate do in cosmetics?
Disodium Pyrophosphate functions as: Anticorrosive, Buffering, Chelating. It is classified as a cosmetic ingredient in our database. CAS number: 7758-16-9.
What is the Margin of Safety for Disodium Pyrophosphate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Disodium Pyrophosphate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Pyrophosphate is 335 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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