Is Disodium Pyrophosphate safe in cosmetics?
Disodium Pyrophosphate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Disodium Pyrophosphate
Also known as: SODIUM ACID PYROPHOSPHATE, EINECS 231-835-0, Dinatriumpyrophosphat, UNII-H5WVD9LZUD
INCI: DISODIUM PYROPHOSPHATE
Disodium Pyrophosphate (CAS 7758-16-9) is a cosmetic cosmetic ingredient functioning as Anticorrosive, Buffering, Chelating. NOAEL 1100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7758-16-9 →
Auto-generated CPSR Part A draft with source citations
Function
Anticorrosive, Buffering, Chelating
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;[hydroxy(oxido)phosphoryl] hydrogen phosphate
InChIKey
GYQBBRRVRKFJRG-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS as food additive (21 CFR); CIR Expert Panel assessed as safe in present practices of use and concentration when formulated to be non-irritating, as part of 31-ingredient phosphoric acid and salts group
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Pyrophosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disodium Pyrophosphate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
9 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >300 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LC50 | >580 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >300 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LEL | >7940 mg/kg-day | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | =2650 mg/kg | Mouse | oral | - | ChemIDplus |
| NOAEL | =145.7 mg/kg-day | Human | oral | - | PPRTV (CPHEA) |
| RfD | =1 mg/kg-day | Human | oral | - | RSL |
| RfD | =4 mg/kg-day | Human | oral | - | RSL |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
An irritant to skin, eyes, and mucous membranes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
DISODIUM DIHYDROGEN DIPHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Chemical reaction regulator
Corrosion inhibitor
Dispersing agent
Dye
Emulsifier
Filler
Flavouring and nutrient
Food preservative
Leavening agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Pyrophosphate.
Regulatory Flags
buffering-agent
chelating-agent
inorganic-salt
gras
cir-reviewed
eye-irritant
ph-adjuster
epa_safer_alternative
fda_food_additive
Known Synonyms
SODIUM ACID PYROPHOSPHATE
EINECS 231-835-0
Dinatriumpyrophosphat
UNII-H5WVD9LZUD
Chemical Function
pH regulating agent
Chelating agent
Corrosion inhibitor
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
animal_products
animal_products
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
animal_products
animal_products
animal_products
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM ACID PYROPHOSPHATE
ChEMBL ID
CHEMBL3184949
Max Phase
2
Frequently Asked Questions
Is Disodium Pyrophosphate allowed in the EU?
Disodium Pyrophosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Pyrophosphate do in cosmetics?
Disodium Pyrophosphate functions as: Anticorrosive, Buffering, Chelating. It is classified as a cosmetic ingredient in our database. CAS number: 7758-16-9.
Is Disodium Pyrophosphate used outside cosmetics?
Disodium Pyrophosphate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Disodium Pyrophosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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