NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Sodium chlorite

Also known as: Chlorous acid, sodium salt, Caswell No. 755, EINECS 231-836-6, EPA Pesticide Chemical Code 020502, Textile (+4 more)

CAS 7758-19-2

Sodium chlorite (CAS 7758-19-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 39 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Sodium Chlorite →

Cross-Vertical Regulatory Divergence

Sodium chlorite is classified GHS Danger (H271, H272, H301, H310, H314, H318, H373, H400) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

Sodium chlorite

CAS Number

7758-19-2

Molecular Formula

ClHO2.Na

InChI Key

UKLNMMHNWFDKNT-UHFFFAOYSA-M

Synonyms

Chlorous acid, sodium saltCaswell No. 755EINECS 231-836-6EPA Pesticide Chemical Code 020502TextileChlorite sodiumUNII-G538EBV4VFNaClO2NaO2Cl

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1990	52

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records

Oxidizing agentBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 39 records

List	Keyword	Source
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
CEDI	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
fracking; water	NY Department of Conservation	CPCat
Europe; Personal care - oral and dental care - teeth whitener	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 49 of 49 studies

Value	Unit	Endpoint	Route	Species	Source
75.4	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
=0.28	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
G538EBV4VF	UNII	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP ICE cancer
0.23	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=35.5	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB ToxRefDB
=35.5	mg/kg bw/day	LEL	oral	rabbit (new zealand white; New Zealand White)	EPA ToxRefDB v3
25	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=50	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=100	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=300	mg/L	LOAEL	oral	Rat	ECHA
35.5	mg/kg bw/day	LOEL	Oral	Rabbit	NTP ICE dart
0	unitless	Model Score	-	-	NTP ICE endocrine
=13	mg/kg bw/day	NEL	oral	Rabbit	ToxValDB ToxRefDB
=13	mg/kg bw/day	NEL	oral	rabbit (new zealand white; New Zealand White)	EPA ToxRefDB v3
0.77	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
1.7	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=1.9	mg/kg bw/day	NOAEL	oral	Mouse	ECHA
=3	mg/kg/day	NOAEL	oral	-	Regulatory source
4	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
<5	mg/kg bw/day	NOAEL	oral	Rat	ECHA
7	mg/kg bw/day	NOAEL	oral	cat	COSMOS DB
10	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=10	mg/kg bw/day	NOAEL	oral	Rat	ECHA
21	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
23	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
25	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
>25	mg/kg bw/day	NOAEL	oral	Rat	ECHA
32	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=35	ppm	NOAEL	oral	Rat	ECHA
50	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
53	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS DB
59	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
63	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
67	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
=70	mg/L	NOAEL	oral	Rat	ECHA
>75	mg/L	NOAEL	oral	Mouse	ECHA
>100	mg/kg bw/day	NOAEL	oral	Rat	ECHA
>=32	mg/kg bw/day	NOEL	oral	Rat	ECHA
>=32.1	mg/kg bw/day	NOEL	oral	Rat	ECHA
>=40.9	mg/kg bw/day	NOEL	oral	Rat	ECHA
>=41	mg/kg bw/day	NOEL	oral	Rat	ECHA
>=58	mg/kg bw/day	NOEL	oral	Mouse	ECHA
>=83	mg/kg bw/day	NOEL	oral	Mouse	ECHA
>=126	mg/kg bw/day	NOEL	oral	Mouse	ECHA
=0.03	mg/kg bw/day	RfD	oral	Human	ToxValDB RSL
=0.03	mg/kg/day	RfD	oral	-	Regulatory source
=0.1	mg/kg bw/day	RfD	oral	Human	ToxValDB RSL

Showing 49 of 49 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Sodium chlorite	231-836-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1887585

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Sodium chlorite?

Sodium chlorite has 49 NOAEL studies in the database. The lowest reported value is 0.03 mg/kg bw/day via oral in Human. Source: ToxValDB RSL.

What regulatory lists include Sodium chlorite?

Sodium chlorite appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Europe; Specialty occupational products, active_ingredient; Pesticides, and 7 more. Source: EPA CPDat.

Is Sodium chlorite a carcinogen according to IARC?

Sodium chlorite is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1990). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Sodium chlorite used in cosmetics?

Yes, Sodium chlorite is also indexed as a cosmetic ingredient under the name Sodium Chlorite. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium chlorite come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium chlorite have different safety status in cosmetics vs industrial chemicals?

Sodium chlorite is classified GHS Danger (H271, H272, H301, H310, H314, H318, H373, H400) in the chemicals database but is restricted in EU cosmetics.

Is Sodium chlorite used outside industrial chemicals?

Sodium chlorite also appears in cosmetics, pharmaceutical, food safety, cannabis databases.