What is the NOAEL for Sodium chlorite?
Sodium chlorite has 56 NOAEL studies in the database. The lowest reported value is 0.28 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Sodium chlorite
Also known as: Chlorous acid, sodium salt, Caswell No. 755, EINECS 231-836-6, EPA Pesticide Chemical Code 020502, Textile (+4 more)
CAS 7758-19-2
Sodium chlorite (CAS 7758-19-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 39 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Sodium chlorite is classified GHS Danger (H271, H272, H301, H310, H314, H318, H373, H400) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
56
SOURCE
chemical inventory jurisdictions
Regulatory lists
39
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Sodium chlorite
CAS Number
7758-19-2
DTXSID
DTXSID8021272
Molecular Formula
ClHO2.Na
InChI Key
UKLNMMHNWFDKNT-UHFFFAOYSA-M
Synonyms
Chlorous acid, sodium saltCaswell No. 755EINECS 231-836-6EPA Pesticide Chemical Code 020502TextileChlorite sodiumUNII-G538EBV4VFNaClO2NaO2Cl
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1990 | 52 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
Oxidizing agentBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
39 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 56 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 75.4 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =0.28 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| G538EBV4VF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G538EBV4VF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G538EBV4VF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G538EBV4VF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.23 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =35.5 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ToxRefDB |
| =35.5 | mg/kg bw/day | LEL | oral | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| 25 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/L | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 35.5 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP_ICE_dart |
| 35.5 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP_ICE_dart |
| 35.5 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP_ICE_dart |
| 35.5 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP_ICE_dart |
| 35.5 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP_ICE_dart |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =13 | mg/kg bw/day | NEL | oral | Rabbit | ToxValDB_ToxRefDB |
| =13 | mg/kg bw/day | NEL | oral | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| 0.77 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1.7 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1.9 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =3 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| 4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| <5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 7 | mg/kg bw/day | NOAEL | oral | cat | COSMOS_DB |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 21 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 23 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 25 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| >25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 32 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =35 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 53 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 59 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 63 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 67 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =70 | mg/L | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >75 | mg/L | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=32 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=32.1 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=40.9 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=41 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 50 of 56 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium chlorite | 231-836-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1887585
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sodium chlorite?
Sodium chlorite appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Europe; Specialty occupational products, active_ingredient; Pesticides, and 7 more. Source: EPA CPDat.
Is Sodium chlorite a carcinogen according to IARC?
Sodium chlorite is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1990). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Sodium chlorite used in cosmetics?
Yes, Sodium chlorite is also indexed as a cosmetic ingredient under the name Sodium Chlorite. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium chlorite come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium chlorite have different safety status in cosmetics vs industrial chemicals?
Sodium chlorite is classified GHS Danger (H271, H272, H301, H310, H314, H318, H373, H400) in the chemicals database but is restricted in EU cosmetics.
Is Sodium chlorite used outside industrial chemicals?
Sodium chlorite also appears in cosmetics, pharmaceutical, food safety, cannabis databases.