Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Chlorite. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 53 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 53 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 7 mg/kg bw/day | oral | cat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 63 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 32 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 408 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
ECHA CLH proposal for potential CMR classification (carcinogenic, mutagenic, reprotoxic); if classified, would require Annex III defense or face Annex II ban; monitor regulatory developments closely
Regulatory Flags
Frequently Asked Questions
Is Sodium Chlorite safe in cosmetics?
ECHA CLH proposal for potential CMR classification (carcinogenic, mutagenic, reprotoxic); if classified, would require Annex III defense or face Annex II ban; monitor regulatory developments closely The EU classifies Sodium Chlorite as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Chlorite allowed in the EU?
Sodium Chlorite EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Chlorite do in cosmetics?
Sodium Chlorite functions as: Oxidizing agent, antimicrobial, oral care agent (tooth whitening). It is classified as a cosmetic ingredient in our database. CAS number: 7758-19-2.
What is the Margin of Safety for Sodium Chlorite?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Chlorite?
The NOAEL (No Observed Adverse Effect Level) for Sodium Chlorite is 53 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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