What is the NOAEL for Tricalcium phosphate?
Tricalcium phosphate has 6 NOAEL studies in the database. The lowest reported value is K4C08XP666 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tricalcium phosphate
Also known as: Calcium orthophosphate, tri-(tert), Caswell No. 148, EINECS 231-840-8, EPA Pesticide Chemical Code 076401, FEMA No. 3081 (+9 more)
CAS 7758-87-4
Tricalcium phosphate (CAS 7758-87-4) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Tricalcium phosphate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Tricalcium phosphate
CAS Number
7758-87-4
DTXSID
DTXSID1049803
Molecular Formula
3Ca.2H3O4P
InChI Key
QORWJWZARLRLPR-UHFFFAOYSA-H
Monoisotopic Mass
315.841564
Synonyms
Calcium orthophosphate, tri-(tert)Caswell No. 148EINECS 231-840-8EPA Pesticide Chemical Code 076401FEMA No. 3081Natural whitlockiteUNII-K4C08XP666JAX TCPCa3(PO4)2Calcigenol SimpleCalcium phosphate tribasiccalcium phosphate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
40 records
AbrasiveDeodorizerOpaciferAnti-caking agentFragranceFillerFlavouring and nutrientOtherHumectantDrierThickening agentEmulsifierProcessing aids not otherwise specifiedpH regulating agentLeavening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| K4C08XP666 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K4C08XP666 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K4C08XP666 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K4C08XP666 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =240 | mg/kg bw/day | NOAEL (HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =8 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tricalcium bis(orthophosphate) | 231-840-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CALCIUM PHOSPHATE, TRIBASIC
ChEMBL Phase
3
Adverse Events
15
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E341 — ADI: 70 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tricalcium phosphate?
Tricalcium phosphate appears on 5 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), active_ingredient; Europe; Pesticides, inert_ingredient; Pesticides, and 2 more. Source: EPA CPDat.
Is Tricalcium phosphate used in cosmetics?
Yes, Tricalcium phosphate is also indexed as a cosmetic ingredient under the name Tricalcium Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tricalcium phosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Tricalcium phosphate have different safety status in cosmetics vs industrial chemicals?
Tricalcium phosphate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Tricalcium phosphate used outside industrial chemicals?
Tricalcium phosphate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.