What is the NOAEL for Diammonium hydrogen phosphate?
Diammonium hydrogen phosphate has 62 NOAEL studies in the database. The lowest reported value is 0.09 mg/kg bw/day via oral in Human. Source: ToxValDB_PPRTV_(CPHEA).
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diammonium hydrogen phosphate
Also known as: Ammonium dibasic phosphate, Ammonium monohydrogen orthophosphate, Ammonium monohydrogen phosphate, Ammonium orthophosphate dibasic, Diammonium acid phosphate (+15 more)
CAS 7783-28-0
Diammonium hydrogen phosphate (CAS 7783-28-0) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
62
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Diammonium hydrogen phosphate
CAS Number
7783-28-0
DTXSID
DTXSID6029705
Molecular Formula
2H3N.H3O4P
InChI Key
MNNHAPBLZZVQHP-UHFFFAOYSA-N
Monoisotopic Mass
132.029994
Synonyms
Ammonium dibasic phosphateAmmonium monohydrogen orthophosphateAmmonium monohydrogen phosphateAmmonium orthophosphate dibasicDiammonium acid phosphateHydrogen diammonium phosphatePhosphoric acid ammonium salt (1:2)Phosphoric acid, diammonium saltAmmonium hydrogen phosphateDiammonium hydrogen phosphate ((NH4)HPO4)Ammonium phosphate ((NH4)2(HPO4))Phos-Check
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
21 records
pH regulating agentCorrosion inhibitorFlame retardantSoil amendmentsFlavouring and nutrientLeavening agentStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 62 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.30.3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-1.51.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-1.51.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-66 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-66 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =12 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =12 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-12.512.5 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-12.512.5 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-2525 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-2525 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-3030 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:0-3030 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =100 | mg/L | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =100 | mg/L | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =27.7 | mg/kg bw/day | BMDL (10 HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =5.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 10LGE70FSU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10LGE70FSU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10LGE70FSU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10LGE70FSU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =50 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =200 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =200 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| ~330 | mg/kg bw/day | NOAEL | oral | Rat; Dog | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| ~330 | mg/kg bw/day | NOAEL | oral | Rat; Dog | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =631 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =631 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =647 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =647 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:636-11131113 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| range:636-11131113 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| >=1500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2500 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =2500 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =2680 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =2680 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =2750 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =2750 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =3000 | mg/kg bw/day | NOAEL | oral | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =3000 | mg/kg bw/day | NOAEL | oral | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| =3044 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v1007je01 |
Showing 50 of 62 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diammonium hydrogenorthophosphate | 231-987-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
AMMONIUM PHOSPHATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E342ii — 1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Diammonium hydrogen phosphate?
Diammonium hydrogen phosphate appears on 6 regulatory/inventory lists including Australia; Food and drug - smoking-related products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.
Is Diammonium hydrogen phosphate used in cosmetics?
Yes, Diammonium hydrogen phosphate is also indexed as a cosmetic ingredient under the name Diammonium Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diammonium hydrogen phosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Diammonium hydrogen phosphate used outside industrial chemicals?
Diammonium hydrogen phosphate also appears in cosmetics, pharmaceutical, food safety databases.