Is Diammonium Phosphate safe in cosmetics?
Diammonium Phosphate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Diammonium Phosphate
Also known as: Ammonium dibasic phosphate, Ammonium monohydrogen orthophosphate, Ammonium monohydrogen phosphate, Ammonium orthophosphate dibasic, Diammonium acid phosphate (+15 more)
INCI: DIAMMONIUM PHOSPHATE
Diammonium Phosphate (CAS 7783-28-0) is a cosmetic cosmetic ingredient functioning as Buffering agent (pH adjuster). Reported NOAEL =50 mg/kg bw/day in Human; Rat (INCHEM_WHO_jecfa_jecmono_v1007je01); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7783-28-0 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering agent (pH adjuster)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
diazanium;hydrogen phosphate
InChIKey
MNNHAPBLZZVQHP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FDA affirmed GRAS; CIR Expert Panel concluded safe in present practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diammonium Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Diammonium Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Human; Rat | Reproductive toxicity | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =50 mg/kg bw/day | oral | Human; Rat | Reproductive toxicity | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =200 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =200 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =631 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =631 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =647 mg/kg bw/day | - | Rat | Developmental toxicity | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =647 mg/kg bw/day | - | Rat | Developmental toxicity | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =2500 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
| NOAEL | =2500 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1007je01 |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0217
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Dust irritating to eyes, and throat. Solid irritating to skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
DIAMMONIUM HYDROGEN PHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Corrosion inhibitor
Flame retardant
Flavouring and nutrient
Leavening agent
Soil amendments
Stabilizing agent
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Diammonium Phosphate.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diammonium Phosphate by CAS number or substance name.
Studies
28
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
7354 mg/kg bw/day
INCHEM_WHO_jecfa_jecmono_v1007je01
Known Synonyms
Ammonium dibasic phosphate
Ammonium monohydrogen orthophosphate
Ammonium monohydrogen phosphate
Ammonium orthophosphate dibasic
Diammonium acid phosphate
Hydrogen diammonium phosphate
Phosphoric acid ammonium salt (1:2)
Phosphoric acid, diammonium salt
Ammonium hydrogen phosphate
Diammonium hydrogen phosphate ((NH4)HPO4)
Ammonium phosphate ((NH4)2(HPO4))
Phos-Check
Akoustan A
AMMONIUM PHOSPHATE DIBASIC
Ammonium phosphate secondary
AMMONIUM-HYDROGENPHOSPHAT
Coaltrol LPA 445
DIAMMONIUM HYDROGEN ORTHOPHOSPHATE
Phos-Chek 202A
Spartan AR 295
Chemical Function
pH regulating agent
Corrosion inhibitor
Flame retardant
Soil amendments
Flavouring and nutrient
Regulatory Lists
Australia; Food and drug - smoking-related products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMMONIUM PHOSPHATE
ChEMBL ID
CHEMBL2105954
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Diammonium phosphate
E Number
E342ii
Food Category
flavor_enhancer
Frequently Asked Questions
Is Diammonium Phosphate allowed in the EU?
Diammonium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diammonium Phosphate do in cosmetics?
Diammonium Phosphate functions as: Buffering agent (pH adjuster). It is classified as a cosmetic ingredient in our database. CAS number: 7783-28-0.
What is the NOAEL for Diammonium Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Diammonium Phosphate is =50 mg/kg bw/day based on a Reproductive toxicity study via oral route in Human; Rat. A total of 10 study endpoints are available. Source: INCHEM_WHO_jecfa_jecmono_v1007je01.
Is Diammonium Phosphate used outside cosmetics?
Diammonium Phosphate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diammonium Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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