What is the NOAEL for Diazolidinyl urea?
Diazolidinyl urea has 20 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diazolidinyl urea
Also known as: Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-, Diazolidinylurea, N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea, EINECS 278-928-2, N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea (+2 more)
CAS 78491-02-8
Diazolidinyl urea (CAS 78491-02-8) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
20
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Diazolidinyl urea
CAS Number
78491-02-8
Molecular Formula
C8H14N4O7
InChI Key
SOROIESOUPGGFO-UHFFFAOYSA-N
Monoisotopic Mass
278.086249
Synonyms
Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-DiazolidinylureaN-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)ureaEINECS 278-928-2N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)ureaImidazolidinyl urea 11UNII-H5RIZ3MPW4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Personal care - general moisturizing | P&G | Proctor & Gamble |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.1147 | uM | AC50 | - | - | NTP ICE endocrine |
| 0.002729 | uM | ACC | - | - | NTP ICE endocrine |
| =20.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| H5RIZ3MPW4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N9VX1IBW6K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2600 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2900 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3800 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4200 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1600 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.251 | unitless | Model Score | - | - | NTP ICE endocrine |
| =0.1 | - | NOAEL | oral | rat | CIR Safety Assessment |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =300 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =200 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| =250 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea | 278-928-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.5% (face leave-on); 0.6% (rinse-off)
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3187032
ChEMBL Phase
Not listed
Adverse Events
1
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diazolidinyl urea?
Diazolidinyl urea appears on 8 regulatory/inventory lists including active_ingredient; Europe; Pesticides, inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, and 5 more. Source: EPA CPDat.
Is Diazolidinyl urea used in cosmetics?
Yes, Diazolidinyl urea is also indexed as a cosmetic ingredient under the name Diazolidinyl Urea. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diazolidinyl urea come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diazolidinyl urea used outside industrial chemicals?
Diazolidinyl urea also appears in cosmetics, pharmaceutical databases.