Also known as: 2-Propenoic acid, 2-methyl-, 2-methylpropenoic acid, 2-Methylprop-2-enoic acid, 4-02-00-01518, Acrylic acid, 2-methyl- (+12 more)
CAS 79-41-4
Methacrylic acid (CAS 79-41-4) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H314. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Methacrylic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H302, H314).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A | H312; H302; H314 | GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Toxic in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 20 ppm (70 mg/m³) | 20 | 70 | Y |
| ACGIH | TWA | 20 ppm [1992] | 20 | - | N |
| CAL/OSHA | TWA | 20 ppm (70 mg/m³) | 20 | 70 | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =44 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =39.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1CS02G8656 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1CS02G8656 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1CS02G8656 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1CS02G8656 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6.9674 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 7.1 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1060 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1320 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2224 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =56337.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =352 | mg/m3 | NOAEL | inhalation | rat | CIR_vision_codex |
| =352 | mg/m3 | NOAEL | inhalation | rat | CIR_vision_codex |
| =352 | mg/m3 | NOAEL | inhalation | rat | CIR_vision_codex |
| =352 | mg/m3 | NOAEL | inhalation | rat | CIR_vision_codex |
| 352 | mg/m3 | repeated dose toxicity | inhalation | rat | UnifiedCodex:CIR:beta.noael_studies |
Showing 17 of 17 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methacrylic acid | 201-204-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Methacrylic acid (CAS 79-41-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A with signal word Danger. Hazard statements: H312; H302; H314. Source: EU CLP Annex VI (ECHA).
Methacrylic acid has 17 NOAEL studies in the database. The lowest reported value is 39.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Methacrylic acid appears on 4 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Occupational exposure limits for Methacrylic acid are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Methacrylic acid is also indexed as a cosmetic ingredient under the name Methacrylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Methacrylic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H302, H314).
Methacrylic acid also appears in cosmetics, pharmaceutical, cannabis databases.