Methacrylic Acid

Corrosive to skin and eyes; causes severe burns (GHS H314). Harmful if swallowed or inhaled. In finished cosmetic products, it is almost always present in neutralized or polymerized form, which dramatically reduces hazard. pKa ~4.65; the methyl group provides greater hydrophobicity and hardness in derived polymers compared to acrylic acid-based polymers. Key building block for Eudragit-type and carbomer-adjacent systems The EU classifies Methacrylic Acid as "prohibited". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.

Methacrylic Acid EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

Methacrylic Acid functions as: Buffering agent; also functions as a polymerization monomer for cosmetic-grade copolymers. It is classified as a cosmetic ingredient in our database. CAS number: 79-41-4.

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for Methacrylic Acid is >=124.1 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.

Methacrylic Acid carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Toxic in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.