What is the NOAEL for Alpha-Irone?
Alpha-Irone has 8 NOAEL studies in the database. The lowest reported value is O3M0L879K6 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Alpha-Irone
Also known as: Methyl-alpha-ionone, 3-Buten-2-one, 4-(2,5,6,6-tetramethyl-2-cyclohexen-1-yl)-, alpha-Ionone, methyl-, alpha-Ionone, 6-methyl-, 4-(2,5,6,6-Tetramethyl-2-cyclohexen-1-yl)-3-butene-2-one (+11 more)
CAS 79-69-6
Alpha-Irone (CAS 79-69-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Alpha-Irone
CAS Number
79-69-6
DTXSID
DTXSID4047042
Molecular Formula
C14H22O
InChI Key
JZQOJFLIJNRDHK-UHFFFAOYSA-N
Monoisotopic Mass
206.167065
Synonyms
Methyl-alpha-ionone3-Buten-2-one, 4-(2,5,6,6-tetramethyl-2-cyclohexen-1-yl)-alpha-Ionone, methyl-alpha-Ionone, 6-methyl-4-(2,5,6,6-Tetramethyl-2-cyclohexen-1-yl)-3-butene-2-one6-Methyl-alpha-iononeBRN 1343498Cyclocitrylidenebutanone, alpha-Cyclocitrylidenemethyl ethyl ketone, alpha-EINECS 201-219-6FEMA No. 2597alpha-Inone, methyl-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| O3M0L879K6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O3M0L879K6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O3M0L879K6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O3M0L879K6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5.9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-(2,5,6,6-tetramethylcyclohex-2-enyl)but-3-en-2-one | 201-219-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Alpha-Irone?
Alpha-Irone appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Alpha-Irone used in cosmetics?
Yes, Alpha-Irone is also indexed as a cosmetic ingredient under the name 5-Methyl-Alpha-Ionone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Irone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Alpha-Irone used outside industrial chemicals?
Alpha-Irone also appears in cosmetics, food safety, cannabis databases.