What is the NOAEL for 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol?
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol has 10 NOAEL studies in the database. The lowest reported value is 1.15 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol
Also known as: 1,4-Benzenediol, 2,5-bis(1,1-dimethylpropyl)-, 3-06-00-04748, Antage DAH, 2,5-Bis(1,1-dimethylpropyl)hydroquinone, BRN 2214556 (+12 more)
CAS 79-74-3
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol (CAS 79-74-3) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317, H400, H410, H371).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol
CAS Number
79-74-3
DTXSID
DTXSID5044992
Molecular Formula
C16H26O2
InChI Key
CZNRFEXEPBITDS-UHFFFAOYSA-N
Monoisotopic Mass
250.19328
Synonyms
1,4-Benzenediol, 2,5-bis(1,1-dimethylpropyl)-3-06-00-04748Antage DAH2,5-Bis(1,1-dimethylpropyl)hydroquinoneBRN 22145562,5-Di-tert-amylbenzene-1,4-diol2,5-Di-tert-amylhydroquinone2,5-Di-tert-pentylbenzene-1,4-diolEINECS 201-222-2Hydroquinone, 2,5-di-tert-amyl-Hydroquinone, 2,5-di-t-pentyl-NSC 455
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
AntioxidantHeat stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 11.4 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1.15 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 19O4J76TTK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19O4J76TTK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19O4J76TTK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19O4J76TTK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0166 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =70 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,5-di-tert-pentylhydroquinone | 201-222-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL594135
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol?
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol used in cosmetics?
Yes, 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol is also indexed as a cosmetic ingredient under the name Diamylhydroquinone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol have different safety status in cosmetics vs industrial chemicals?
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317, H400, H410, H371).
Is 2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol used outside industrial chemicals?
2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol also appears in cosmetics, pharmaceutical databases.