Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diamylhydroquinone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 other | oral | rat | oral | REACH |
Expert Verdict
Skin depigmentation risk (ochronosis) and immune-function alteration; renal tubule tumours reported in animal studies; CIR data insufficient to establish safety with identified gaps in concentration-of-use data, impurity profile, UV absorption, dermal toxicity, skin penetration, and genotoxicity assessment.
Frequently Asked Questions
Is Diamylhydroquinone safe in cosmetics?
Skin depigmentation risk (ochronosis) and immune-function alteration; renal tubule tumours reported in animal studies; CIR data insufficient to establish safety with identified gaps in concentration-of-use data, impurity profile, UV absorption, dermal toxicity, skin penetration, and genotoxicity assessment. The EU classifies Diamylhydroquinone as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Diamylhydroquinone allowed in the EU?
Diamylhydroquinone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diamylhydroquinone do in cosmetics?
Diamylhydroquinone functions as: Antioxidant (polymerisation inhibitor / stabiliser). It is classified as a cosmetic ingredient in our database. CAS number: 79-74-3.
What is the Margin of Safety for Diamylhydroquinone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diamylhydroquinone?
The NOAEL (No Observed Adverse Effect Level) for Diamylhydroquinone is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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