What is the NOAEL for Retinol palmitate?
Retinol palmitate has 31 NOAEL studies in the database. The lowest reported value is 1D1K0N0VVC UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Retinol palmitate
Also known as: All-trans-retinyl palmitate, Vitamin A palmitate, BRN 1917366, EINECS 201-228-5, Vitamin A solubilized (+14 more)
CAS 79-81-2
Retinol palmitate (CAS 79-81-2) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Retinol palmitate is classified GHS Danger (H315, H360, H361, H413) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
31
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Retinol palmitate
CAS Number
79-81-2
DTXSID
DTXSID1021241
Molecular Formula
C36H60O2
InChI Key
VYGQUTWHTHXGQB-FFHKNEKCSA-N
Monoisotopic Mass
524.459331
Synonyms
All-trans-retinyl palmitateVitamin A palmitateBRN 1917366EINECS 201-228-5Vitamin A solubilizedUNII-1D1K0N0VVCEster found in fish liver oilsLutavit A 500 PlusMyvakMyvaxOptovit AOptovit-A
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
Softener and conditionerPharmaceuticalAntioxidantFlavouring and nutrientDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 31 of 31 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1D1K0N0VVC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1D1K0N0VVC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1D1K0N0VVC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1D1K0N0VVC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =7910 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =10.368 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =10.752 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 11 | mg/kg bw/day | LOAEL | oral | primate | COSMOS_DB |
| 1.2 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1.4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2.688 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 4.09999990463 | mg/kg bw/day | NOAEL | oral | primate | COSMOS_DB |
| 5.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 14 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 24 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 28 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 30 | mg/kg bw/day | NOAEL | oral | cat | COSMOS_DB |
| 33 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 44 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 55 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 60 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 69 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 74 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 83 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 118 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 138 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 165 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 206 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 220 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| <2.592 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 31 of 31 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Retinyl palmitate | 201-228-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.3%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
VITAMIN A PALMITATE
ChEMBL Phase
4
Adverse Events
1665
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0.8 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Retinol palmitate?
Retinol palmitate appears on 4 regulatory/inventory lists including Europe; supplements, Europe; food_additive; supplements, Europe; Personal care, and 1 more. Source: EPA CPDat.
Is Retinol palmitate used in cosmetics?
Yes, Retinol palmitate is also indexed as a cosmetic ingredient under the name Retinyl Palmitate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Retinol palmitate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Retinol palmitate have different safety status in cosmetics vs industrial chemicals?
Retinol palmitate is classified GHS Danger (H315, H360, H361, H413) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
Is Retinol palmitate used outside industrial chemicals?
Retinol palmitate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.