Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Retinyl Palmitate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 138 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 28 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 14 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 220 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1100 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 138 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | cat | Chronic | COSMOS_DB |
| NOAEL | 1.2 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 138 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 138 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Retinyl Palmitate, relevant to systemic exposure and MoS calculations.
Source: SCCS/1378/10
Expert Verdict
Least potent retinoid ester requiring three-step conversion to retinoic acid, with primary cosmetic value as antioxidant and emollient rather than anti-aging signaling molecule; good tolerability profile.
Regulatory Flags
Frequently Asked Questions
Is Retinyl Palmitate safe in cosmetics?
Least potent retinoid ester requiring three-step conversion to retinoic acid, with primary cosmetic value as antioxidant and emollient rather than anti-aging signaling molecule; good tolerability profile. The EU classifies Retinyl Palmitate as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Retinyl Palmitate allowed in the EU?
Retinyl Palmitate EU regulatory status: restricted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinyl Palmitate do in cosmetics?
Retinyl Palmitate functions as: skin-conditioning, antioxidant. It is classified as a Active Ingredient in our database. CAS number: 79-81-2.
What is the Margin of Safety for Retinyl Palmitate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Retinyl Palmitate?
The NOAEL (No Observed Adverse Effect Level) for Retinyl Palmitate is 138 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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