What is the NOAEL for Camphene?
Camphene has 38 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Camphene
Also known as: 2,2-Dimethyl-3-methylenebicyclo[2.2.1]heptane, Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene-, Camphene (2,2-dimethyl-3-methylene-norbornane), 2,2-Dimethyl-3-methylenebicyclo(2.2.1)heptane, 3,3-Dimethyl-2-methylenenorcamphene (+6 more)
CAS 79-92-5
Camphene (CAS 79-92-5) is a chemical substance. Key regulatory status: REACH registered, 27 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Camphene is classified GHS Danger (H228, H304, H319, H400, H410, H401, H411, H226) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
38
SOURCE
chemical inventory jurisdictions
Regulatory lists
27
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Camphene
CAS Number
79-92-5
DTXSID
DTXSID8026488
Molecular Formula
C10H16
InChI Key
CRPUJAZIXJMDBK-UHFFFAOYSA-N
Monoisotopic Mass
136.125201
Synonyms
2,2-Dimethyl-3-methylenebicyclo[2.2.1]heptaneBicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene-Camphene (2,2-dimethyl-3-methylene-norbornane)2,2-Dimethyl-3-methylenebicyclo(2.2.1)heptane3,3-Dimethyl-2-methylenenorcampheneEINECS 201-234-8EINECS 209-275-3FEMA No. 2229UNII-G3VG94Z26E3,3-dimethyl-2-methylidenebicyclo[2.2.1]heptaneComphene
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable solid Causes eye irritation Very toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerNo specific technical functionFlavouring and nutrientDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
27 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 38 of 38 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =110.19 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| G3VG94Z26E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G3VG94Z26E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G3VG94Z26E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G3VG94Z26E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.04 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.04 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.04 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.04 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 100 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 100 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 100 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 100 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =222 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <62.5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 4 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 4 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 4 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 4 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 38 of 38 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Camphene | 201-234-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
terpene
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CAMPHENE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Camphene?
Camphene appears on 20 regulatory/inventory lists including detected; Europe; Personal care - sexual wellness, inert_ingredient; non_food_use; Pesticides, air; consumer_product; detected; emissions, and 17 more. Source: EPA CPDat.
Is Camphene used in cosmetics?
Yes, Camphene is also indexed as a cosmetic ingredient under the name Camphene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Camphene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Camphene have different safety status in cosmetics vs industrial chemicals?
Camphene is classified GHS Danger (H228, H304, H319, H400, H410, H401, H411, H226) in the chemicals database but is allowed in EU cosmetics.
Is Camphene used outside industrial chemicals?
Camphene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.