Danger GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

2-(4-Tert-Butylbenzyl)propionaldehyde

Also known as: Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl- (2-(4-tert-Butylbenzyl)propionaldehyde) (3-(4-tert-butylphenyl)-2-methylpropanal), Lilial, Benzenepropanal, 4-(1,1-dimethylethyl)-.alpha.-methyl-, Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl-, 4-07-00-00802 (+10 more)

CAS 80-54-6

2-(4-Tert-Butylbenzyl)propionaldehyde (CAS 80-54-6) is a chemical substance with GHS signal word Danger; key hazard signal: H360Fd. Key regulatory status: REACH registered, 37 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Butylphenyl Methylpropional (Lilial) →

SOURCE NOAEL studies
NOAEL studies
56
SOURCE Chemical inventory jurisdictions
Regulatory lists
37
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
2-(4-Tert-Butylbenzyl)propionaldehyde
CAS Number
80-54-6
Molecular Formula
C14H20O
InChI Key
SDQFDHOLCGWZPU-UHFFFAOYSA-N
Monoisotopic Mass
204.151415
Synonyms
Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl- (2-(4-tert-Butylbenzyl)propionaldehyde) (3-(4-tert-butylphenyl)-2-methylpropanal)LilialBenzenepropanal, 4-(1,1-dimethylethyl)-.alpha.-methyl-Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl-4-07-00-00802BRN 0880140p-tert-Butyl-alpha-methyldihydrocinnamic aldehydep-tert-Butyl-alpha-methylhydrocinnamaldehydep-tert-Butyl-alpha-methylhydrocinnamic aldehydeEINECS 201-289-8alpha-Methyl, beta-(p-tert-butylphenyl)propionaldehydealpha-Methyl-p-(tert-butyl)hydrocinnamaldehyde

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 1BH360FdGHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 37 records
ListKeywordSource
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA
EuropeDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry detergent; EuropeDanish EPADanish EPA
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; EuropeDanish EPADanish EPA
Cleaning products and household care; EuropeDanish EPADanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment; detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
consumer_product; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; PesticidesDanish EPADanish EPA
detected; Europe; PesticidesDanish EPADanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
Europe; Personal care; restrictedEuropean CommissionCosIng
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry detergent; EuropeDanish EPADanish EPA
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; EuropeDanish EPADanish EPA
Cleaning products and household care; EuropeDanish EPADanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 56 studies
ValueUnitEndpointRouteSpeciesSource
=0.0281mg/kg bw-oralratRegulatory source
=1.4mg/kg bw-oralratRegulatory source
=5mg/kg bw/d-oralratRegulatory source
5mg/kg bw/d---Regulatory source
50%-oralhumanRegulatory source
29.06uMAC50--NTP ICE endocrine
24.51uMACC--NTP ICE endocrine
44.6ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
6.1ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
8.93ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
34.16ug/mLCV70Dermal-NTP ICE skin sensitization
42.2ug/mLCV75Dermal-NTP ICE skin sensitization
281.3%Concentration, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
25%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
=0.44mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
-1.3%Depletion CysDermal-NTP ICE skin sensitization
14%Depletion CysDermal-NTP ICE skin sensitization
0.7%Depletion LysDermal-NTP ICE skin sensitization
0.8%Depletion LysDermal-NTP ICE skin sensitization
0.4%Depletion Lys + CysDermal-NTP ICE skin sensitization
7.35%Depletion Lys + CysDermal-NTP ICE skin sensitization
>2000uMEC1.5Dermal-NTP ICE skin sensitization
18.7%EC3DermalMouseNTP ICE skin sensitization
19%EC3DermalMouseNTP ICE skin sensitization
147minET50Dermal-NTP ICE skin irritation
154minET50Dermal-NTP ICE skin irritation
162minET50Dermal-NTP ICE skin irritation
176minET50Dermal-NTP ICE skin irritation
179minET50Dermal-NTP ICE skin irritation
186minET50Dermal-NTP ICE skin irritation
195minET50Dermal-NTP ICE skin irritation
196minET50Dermal-NTP ICE skin irritation
201minET50Dermal-NTP ICE skin irritation
T7540GJV69UNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP ICE eye irritation
94.49uMIC50Dermal-NTP ICE skin sensitization
1.15ratioImaxDermal-NTP ICE skin sensitization
0%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
0.4444%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
2592ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
3240ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
2.953e+4ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
3.322e+5ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
2.953e+4ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP ICE skin sensitization
=1390mg/kg bwLD50oralRatNTP ICE acute oral
0unitlessModel Score--NTP ICE endocrine
0.0022unitlessModel Score--NTP ICE endocrine
=0.0281mg/kg bwNOAELoralratSCCS Opinion
=1.4mg/kg bwNOAELoralratSCCS Opinion
=4.5mg/kg bw/dNOAEL--SCCS Opinion

Showing 50 of 56 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-(4-tert-butylbenzyl)propionaldehyde201-289-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1591/1710 May 2019Not safe (aggregate exposure MoS <100); banned in EU cosmetics from March 2022N/A (banned from EU cosmetics)Aggregate exposure exceeds safe threshold; skin sensitisation; CMR 1B (H360FD) reproductive toxicity; mutagenicity concerns
SCCS/1540/1416 March 2016Not safe at any proposed IFRA concentration limits (MoS=3.6 or MoS=53 with revised limits)N/A (not safe at any limit)Skin sensitisation confirmed in humans; mutagenicity inconclusive; insufficient usage data; later confirmed as CMR 1B

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1496715
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-(4-Tert-Butylbenzyl)propionaldehyde?

2-(4-Tert-Butylbenzyl)propionaldehyde (CAS 80-54-6) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360Fd. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-(4-Tert-Butylbenzyl)propionaldehyde?

2-(4-Tert-Butylbenzyl)propionaldehyde has 56 NOAEL studies in the database. The lowest reported value is -1.3 % via Dermal. Source: NTP ICE skin sensitization.

What regulatory lists include 2-(4-Tert-Butylbenzyl)propionaldehyde?

2-(4-Tert-Butylbenzyl)propionaldehyde appears on 20 regulatory/inventory lists including Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener, Europe, inert_ingredient; non_food_use; Pesticides, and 17 more. Source: EPA CPDat.

Is 2-(4-Tert-Butylbenzyl)propionaldehyde used in cosmetics?

Yes, 2-(4-Tert-Butylbenzyl)propionaldehyde is also indexed as a cosmetic ingredient under the name Butylphenyl Methylpropional (Lilial). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-(4-Tert-Butylbenzyl)propionaldehyde come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-(4-Tert-Butylbenzyl)propionaldehyde have different safety status in cosmetics vs industrial chemicals?

2-(4-Tert-Butylbenzyl)propionaldehyde is prohibited in EU cosmetics but has active industrial GHS classifications (H360Fd).

Is 2-(4-Tert-Butylbenzyl)propionaldehyde used outside industrial chemicals?

2-(4-Tert-Butylbenzyl)propionaldehyde also appears in cosmetics, pharmaceutical databases.