Poor Cosmetic Ingredient Sensitization Data

Butylphenyl Methylpropional (Lilial)

INCI: BUTYLPHENYL METHYLPROPIONAL

CAS Number
80-54-6
Function
Fragrance, Masking
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Inadequate - Cannot be established; CMR 1B classification precludes safety demonstration without prohibited animal tests

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Butylphenyl Methylpropional (Lilial) based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.5%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/SCCS (banned 2022)

Expert Verdict

Banned. Classified Repr. 1B (CMR 1B) under CLP Regulation (EU) 2020/1182. Known contact allergen. Must not be present in any cosmetic product on EU/UK market. Also banned in UK since Oct/Dec 2022.

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component eu_children_restricted ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Butylphenyl Methylpropional (Lilial) safe in cosmetics?

Banned. Classified Repr. 1B (CMR 1B) under CLP Regulation (EU) 2020/1182. Known contact allergen. Must not be present in any cosmetic product on EU/UK market. Also banned in UK since Oct/Dec 2022. The EU classifies Butylphenyl Methylpropional (Lilial) as "prohibited". Safety rating: POOR.

Is Butylphenyl Methylpropional (Lilial) allowed in the EU?

Butylphenyl Methylpropional (Lilial) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Butylphenyl Methylpropional (Lilial) do in cosmetics?

Butylphenyl Methylpropional (Lilial) functions as: Fragrance, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 80-54-6.

What is the Margin of Safety for Butylphenyl Methylpropional (Lilial)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Butylphenyl Methylpropional (Lilial) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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