Also known as: 2-Propenoic acid, 2-methyl-, methyl ester, 4-02-00-01519, Acrylic acid, 2-methyl-, methyl ester, BRN 0605459, EINECS 201-297-1 (+15 more)
CAS 80-62-6
Methyl methacrylate (CAS 80-62-6) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H335; H315; H317. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Methyl methacrylate is classified GHS Danger (H225, H335, H315, H317) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1994 | Sup 7, 60 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1 | H225; H335; H315; H317 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the peripheral nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 100 ppm (410 mg/m³) | 100 | 410 | N |
| NIOSH | TWA | 100 ppm (410 mg/m³) | 100 | 410 | N |
| ACGIH | TWA | 50 ppm [1992] | 50 | - | N |
| ACGIH | STEL | 100 ppm [1992] | 100 | - | N |
| CAL/OSHA | TWA | 50 ppm (205 mg/m³) | 50 | 205 | N |
| CAL/OSHA | STEL | 100 ppm (410 mg/m³) | 100 | 410 | N |
| NIOSH | IDLH | 1000 ppm | 1000 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7.2 | mg/m3 | BMC (10 HEC) | inhalation | Rat | ToxValDB_IRIS |
| =25.6 | mg/m3 | BMC (10) | inhalation | Rat | ToxValDB_IRIS |
| =143.317 | mg/m3 | BMC (10) | inhalation | Rat | ToxValDB_IRIS |
| =7.2 | mg/m^3 | BMC 10 (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| 298 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 479.72 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.511 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| 156.78 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 198 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| >1000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 2333 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =208 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =348.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 21 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 42.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 45.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 55.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 11.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 14.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 12.3 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 23.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 29.8 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 33.5 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 424.36 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| <1206 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 60 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 60 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 60 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 60 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 90 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| 196OC77688 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 196OC77688 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 196OC77688 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 196OC77688 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >3000 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.13 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.74 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 7.326 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7874 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 29.0261 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 45.9147 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 49.1885 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
Showing 50 of 87 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl methacrylate | 201-297-1 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Methyl methacrylate | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Methyl methacrylate (CAS 80-62-6) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1 with signal word Danger. Hazard statements: H225; H335; H315; H317. Source: EU CLP Annex VI (ECHA).
Methyl methacrylate has 87 NOAEL studies in the database. The lowest reported value is 0.511 ug/mL via Dermal. Source: NTP_ICE_skin_sensitization.
Methyl methacrylate appears on 12 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Arts and crafts/Office supplies - fabric treatment and dye; detected, and 9 more. Source: EPA CPDat.
Methyl methacrylate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1994). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Methyl methacrylate are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Methyl methacrylate is also indexed as a cosmetic ingredient under the name METHYL METHACRYLATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Methyl methacrylate is classified GHS Danger (H225, H335, H315, H317) in the chemicals database but is allowed in EU cosmetics.
Methyl methacrylate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.