Good Cosmetic Ingredient NOAEL Data GHS Classified Sensitization Data

METHYL METHACRYLATE

CAS Number
80-62-6
Function
Anticaking, Opacifying
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for METHYL METHACRYLATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 ppm other dog other REACH
NOAEL >=124.1 mg/kg bw/day oral rat oral REACH
NOAEL >=124.1 mg/kg bw/day oral rat oral REACH
NOAEL >200 other oral rat oral REACH
NOAEL ca.1.64 mg/L air 1991 hamster inhalation REACH
NOAEL >=1000 ppm 1991 rat inhalation REACH
NOAEL ca.1.64 mg/L air 1991 dog inhalation REACH
NOAEL 1500 ppm 1991 mouse inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the peripheral nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Sensitization Profile

Contact sensitization data for METHYL METHACRYLATE based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG

Expert Verdict

METHYL METHACRYLATE is listed in the EU CosIng database with functions: Anticaking, Opacifying It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment endocrine_disruptor fda_food_additive

Frequently Asked Questions

Is METHYL METHACRYLATE safe in cosmetics?

METHYL METHACRYLATE is listed in the EU CosIng database with functions: Anticaking, Opacifying It is permitted in the EU without specific restrictions. The EU classifies METHYL METHACRYLATE as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is METHYL METHACRYLATE allowed in the EU?

METHYL METHACRYLATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does METHYL METHACRYLATE do in cosmetics?

METHYL METHACRYLATE functions as: Anticaking, Opacifying. It is classified as a cosmetic ingredient in our database. CAS number: 80-62-6.

What is the NOAEL for METHYL METHACRYLATE?

The NOAEL (No Observed Adverse Effect Level) for METHYL METHACRYLATE is 100 ppm based on a other study via other route in dog. A total of 8 study endpoints are available. Source: REACH.

Compliance Tools

Check METHYL METHACRYLATE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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