What is the GHS hazard classification for Petrolatum?
Petrolatum (CAS 8009-03-8) is classified under EU CLP Annex VI as Carc. 1B with signal word Danger. Hazard statements: H350. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
REACH Registered
Cosmetic Ingredient
Petrolatum
Also known as: Caswell No. 645A, EINECS 232-373-2, EPA Pesticide Chemical Code 598400, Extra amber, Mineral fat (+15 more)
CAS 8009-03-8
Petrolatum (CAS 8009-03-8) is a chemical substance with GHS signal word Danger; key hazard signal: H350. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Petrolatum is classified GHS Danger (H350) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
16
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Petrolatum
CAS Number
8009-03-8
DTXSID
DTXSID6027686
Synonyms
Caswell No. 645AEINECS 232-373-2EPA Pesticide Chemical Code 598400Extra amberMineral fatMineral waxPetrolatum, amberPetrolatum USPPetrolatum, yellowProtopet, albaProtopet, white 1SProtopet, white 2L
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B | H350 | GHS08 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Softener and conditionerHumectantUV stabilizerAnti-static agentSolventBinder
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| banned; Europe; Personal care | European Commission | CosIng |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.73 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4T6H12BN9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4T6H12BN9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4T6H12BN9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4T6H12BN9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B6E5W8RQJ4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B6E5W8RQJ4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B6E5W8RQJ4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B6E5W8RQJ4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 15520 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Petrolatum | 232-373-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
905
Bioactivity
0
Frequently Asked Questions
What is the NOAEL for Petrolatum?
Petrolatum has 13 NOAEL studies in the database. The lowest reported value is 2.73 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Petrolatum?
Petrolatum appears on 11 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe; Personal care - liniment, and 8 more. Source: EPA CPDat.
Is Petrolatum used in cosmetics?
Yes, Petrolatum is also indexed as a cosmetic ingredient under the name Vaseline (Petrolatum). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Petrolatum come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Petrolatum have different safety status in cosmetics vs industrial chemicals?
Petrolatum is classified GHS Danger (H350) in the chemicals database but is allowed in EU cosmetics.
Is Petrolatum used outside industrial chemicals?
Petrolatum also appears in cosmetics, pharmaceutical databases.