What is the NOAEL for Dexpanthenol?
Dexpanthenol has 13 NOAEL studies in the database. The lowest reported value is 20 % via oral in mouse. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dexpanthenol
Also known as: (+)-Panthenol, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Cozyme, D-Panthenol 75L, Ilopan (+15 more)
CAS 81-13-0
Dexpanthenol (CAS 81-13-0) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Dexpanthenol
CAS Number
81-13-0
Molecular Formula
C9H19NO4
InChI Key
SNPLKNRPJHDVJA-ZETCQYMHSA-N
Monoisotopic Mass
205.131408
Synonyms
(+)-Panthenol(2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamideCozymeD-Panthenol 75LIlopanPantogelPantol4-04-00-01652BRN 1724947(R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethylbutanamide2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)-D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Softener and conditionerEmulsifierFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 20 | % | - | oral | mouse | Regulatory source |
| =146.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 1O6C93RI7Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1.000e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =3 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =20 | % | NOAEL | oral | mouse | CIR Safety Assessment |
| =200 | mg/kg/d | NOAEL | oral | rat | CIR Safety Assessment |
| =1000 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| >=1000 | mg/kg/day | developmental toxicity | oral | rat | Regulatory source |
| 3 | % | oral toxicity | oral | rat | Regulatory source |
| 200 | mg/kg/d | oral toxicity | oral | rat | Regulatory source |
| 1 | % | repeated dose toxicity | oral | rat | Regulatory source |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dexpanthenol | 201-327-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
DEXPANTHENOL
ChEMBL Phase
4
Adverse Events
1990
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dexpanthenol?
Dexpanthenol appears on 11 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, SCIL (9/2019), food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 8 more. Source: EPA CPDat.
Is Dexpanthenol used in cosmetics?
Yes, Dexpanthenol is also indexed as a cosmetic ingredient under the name PANTHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dexpanthenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dexpanthenol used outside industrial chemicals?
Dexpanthenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.