Excellent Active Ingredient SCCS/CIR Reviewed

PANTHENOL

CAS Number
81-13-0
Function
Humectant; hair conditioner; barrier support
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; no US concentration cap. Effective at 2–5% in leave-on formulations. CIR reviewed and confirmed safe as used. Widely used in sensitive-skin, baby-care, and wound-healing formulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 200 mg/kg/day (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir
Verdict: safe
NOAEL: 200 mg/kg/d (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir
Verdict: safe
NOAEL: 1 % (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir
Verdict: safe
NOAEL: 1 % (not specified)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir
Verdict: safe
NOAEL: 1000 mg/kg/d (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

Expert Verdict

EXCELLENT dual-function soothing and barrier-repair active. Panthenol is enzymatically converted to pantothenic acid in skin, where it serves as coenzyme A precursor essential for fatty acid synthesis and SC lipid metabolism. Clinical evidence demonstrates dose-dependent improvement in skin hydration, TEWL reduction, and anti-inflammatory activity through inhibition of IL-6 and IL-8 release from keratinocytes. Typical effective concentration: 2–5% in leave-on formulations. Widely validated for sensitive-skin, baby-care, and post-procedure applications. Not restricted in EU or US.

⚠️
Concern Level: None

Regulatory Flags

active barrier-repair soothing anti-inflammatory humectant coenzyme-a-precursor il-6-il-8-inhibitor provitamin sensitive-skin baby-safe 2-5pct-effective-dose eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PANTHENOL safe in cosmetics?

EXCELLENT dual-function soothing and barrier-repair active. Panthenol is enzymatically converted to pantothenic acid in skin, where it serves as coenzyme A precursor essential for fatty acid synthesis and SC lipid metabolism. Clinical evidence demonstrates dose-dependent improvement in skin hydration, TEWL reduction, and anti-inflammatory activity through inhibition of IL-6 and IL-8 release from keratinocytes. Typical effective concentration: 2–5% in leave-on formulations. Widely validated for sensitive-skin, baby-care, and post-procedure applications. Not restricted in EU or US. The EU classifies PANTHENOL as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.

Is PANTHENOL allowed in the EU?

PANTHENOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PANTHENOL do in cosmetics?

PANTHENOL functions as: Humectant; hair conditioner; barrier support. It is classified as a Active Ingredient in our database. CAS number: 81-13-0.

What is the Margin of Safety for PANTHENOL?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check PANTHENOL compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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Moderate
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