Danger GHS06GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

1,6-Diisocyanatohexane

Also known as: 1,6-Hexamethylene diisocyanate, 1,6-Diisocyanatohexamethylene, HMDI, NSC 11687, MODIFIED HEXAMETHYL DIISOCYANATE (+12 more)

CAS 822-06-0

1,6-Diisocyanatohexane (CAS 822-06-0) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H335; H315; H319; H334; H317. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for 1,6-Hexamethylene Diisocyanate (HDI) →

SOURCE NOAEL studies
NOAEL studies
51
SOURCE Chemical inventory jurisdictions
Regulatory lists
10
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
1,6-Diisocyanatohexane
CAS Number
822-06-0
Molecular Formula
C8H12N2O2
InChI Key
RRAMGCGOFNQTLD-UHFFFAOYSA-N
Monoisotopic Mass
168.089878
Synonyms
1,6-Hexamethylene diisocyanate1,6-DiisocyanatohexamethyleneHMDINSC 11687MODIFIED HEXAMETHYL DIISOCYANATEUN 2281BRN 0956709EINECS 212-485-8Isocyanic acid, diester with 1,6-hexanediolHexamethylendiisokyanatMetyleno-bis-fenyloizocyjanianSzesciometylenodwuizocyjanian

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1H331; H335; H315; H319; H334; H317GHS06; GHS08Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsFatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction
Short-term EffectsThe substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 4 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA0.005 ppm (0.035 mg/m³)0.0050.035N
NIOSHCEILING0.020 ppm (0.140 mg/m³) [10 minutes]0.020.14N
ACGIHTWA0.005 ppm [1985]0.005-N
CAL/OSHATWA0.005 ppm (0.034 mg/m³)0.0050.034N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 21 records
MonomersSolventChemical reaction regulatorCatalystPolymerization promoterHardenerNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records
ListKeywordSource
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Cons electronics mech appliances and machinery; Europe; nondetectDanish EPADanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies
ValueUnitEndpointRouteSpeciesSource
range123.5ug/mLCD86, EC120Dermal-NTP ICE skin sensitization
=0.035mg/m3DNEL localinhalationHumanToxValDB GESTIS DNEL
84.4%Depletion CysDermal-NTP ICE skin sensitization
49.1%Depletion LysDermal-NTP ICE skin sensitization
range74.32uMEC1.5Dermal-NTP ICE skin sensitization
0.03%EC3DermalMouseNTP ICE skin sensitization
0I70A3I1UFUNIIFDA UNII substance identifier--openFDA substances
0.124mg/LLC50Inhalation-NTP ICE acute inhalation
0.462mg/LLC50Inhalation-NTP ICE acute inhalation
=738mg/kg bwLD50oralRatNTP ICE acute oral
=0.6879mg/m3LELinhalationRatECHA
=1.19mg/m3LELinhalationMouseECHA
=1.54mg/m3LELinhalationMouseECHA
=2.45mg/m3LELinhalationMouseECHA
=2.5mg/m3LELinhalationMouseECHA
=6.71mg/m3LELinhalationMouseECHA
=9.93mg/m3LELinhalationRatECHA
=11.63mg/m3LELinhalationRatECHA
=280mg/m3LELinhalationMouseECHA
=490mg/m3LELinhalationMouseECHA
=0.1204mg/m3LOAECinhalationRatECHA
=2.064mg/m3LOAECinhalationGuinea PigECHA
=3.164mg/m3LOAECinhalationRatECHA
=0.006191mg/m3LOAELinhalationRat (Fischer 344; M/F)Regulatory source
=0.0344mg/m3LOAELinhalationRatToxValDB ATSDR MRLs
=0.0344mg/m3LOAELinhalationRat (Fischer 344; M/F)Regulatory source
=0.06879mg/m3LOAELinhalationRatECHA
=0.175mg/m3LOAELinhalationRatToxValDB IRIS
=0.03mg/m3LOAEL (ADJ)inhalationRatToxValDB IRIS
=0.005mg/m3LOAEL (HEC)inhalationRatToxValDB IRIS
=0.006191mg/m3LOAEL (HEC)inhalationRatToxValDB ATSDR MRLs
=0.00006879mg/m3MRLinhalationHumanToxValDB ATSDR MRLs
=0.0002064mg/m3MRLinhalationHumanToxValDB ATSDR MRLs
0unitlessModel Score--NTP ICE endocrine
=0.6879mg/m3NOAECinhalationGuinea PigECHA
=1.128mg/m3NOAECinhalationRatECHA
=2.064mg/m3NOAECinhalationRatECHA
=0.006191mg/m3NOAELinhalationRat (Sprague Dawley; M/F)Regulatory source
=0.0344mg/m3NOAELinhalationRatToxValDB ATSDR MRLs
=0.0344mg/m3NOAELinhalationRat (Sprague Dawley; M/F)Regulatory source
=0.035mg/m3NOAELinhalationRatToxValDB IRIS
=0.1857mg/m3NOAELinhalationRatToxValDB TX TCEQ
=0.006mg/m3NOAEL (ADJ)inhalationRatToxValDB IRIS
=0.001mg/m3NOAEL (HEC)inhalationRatToxValDB IRIS
=0.001mg/m^3NOAEL (HEC)inhalation-Regulatory source
=0.006191mg/m3NOAEL (HEC)inhalationRatToxValDB ATSDR MRLs
=0.0344mg/m3NOELinhalationRatECHA
=2.064mg/m3NOELinhalationRatECHA
=0.00001mg/m3RfCinhalationHumanToxValDB IRIS
=0.00001mg/m^3RfCinhalation-Regulatory source

Showing 50 of 51 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredHexamethylene diisocyanate212-485-8ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Hexamethylene-1,6-diisocyanate (HDI)N120 - Diisocyanates-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1896533
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane (CAS 822-06-0) is classified under EU CLP Annex VI as Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H331; H335; H315; H319; H334; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane has 51 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane appears on 6 regulatory/inventory lists including detected; Europe; Toys and children's products, Europe; Toys and children's products, CEDI, and 3 more. Source: EPA CPDat.

What are the occupational exposure limits for 1,6-Diisocyanatohexane?

Occupational exposure limits for 1,6-Diisocyanatohexane are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,6-Diisocyanatohexane used in cosmetics?

Yes, 1,6-Diisocyanatohexane is also indexed as a cosmetic ingredient under the name 1,6-Hexamethylene Diisocyanate (HDI). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,6-Diisocyanatohexane come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,6-Diisocyanatohexane have different safety status in cosmetics vs industrial chemicals?

1,6-Diisocyanatohexane is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H335, H315, H319, H334, H317).

Is 1,6-Diisocyanatohexane used outside industrial chemicals?

1,6-Diisocyanatohexane also appears in cosmetics, pharmaceutical databases.