1,6-Hexamethylene Diisocyanate (HDI)

Major hazard associated with occupational asthma, hypersensitivity pneumonitis, rhinitis, accelerated lung deterioration, irritant and allergic contact dermatitis, and skin and conjunctival irritation. Should only appear as quantified residual impurity in polymer ingredients. The EU classifies 1,6-Hexamethylene Diisocyanate (HDI) as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.

1,6-Hexamethylene Diisocyanate (HDI) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

1,6-Hexamethylene Diisocyanate (HDI) functions as: Monomer and crosslinker in polymer synthesis; not a direct cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 822-06-0.

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for 1,6-Hexamethylene Diisocyanate (HDI) is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

1,6-Hexamethylene Diisocyanate (HDI) carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.