NOAEL Data Cosmetic Ingredient

2-Hydroxy-1,4-naphthoquinone

Also known as: 4-08-00-02360, BRN 1565260, EINECS 201-496-3, UNII-TLH4A6LV1W, Henna

CAS 83-72-7

2-Hydroxy-1,4-naphthoquinone (CAS 83-72-7) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Lawsone →

SOURCE noael studies public
NOAEL studies
75
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields
Name
2-Hydroxy-1,4-naphthoquinone
CAS Number
83-72-7
DTXSID
DTXSID2025428
Molecular Formula
C10H6O3
InChI Key
CSFWPUWCSPOLJW-UHFFFAOYSA-N
Monoisotopic Mass
174.031694
Synonyms
4-08-00-02360BRN 1565260EINECS 201-496-3UNII-TLH4A6LV1WHenna

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 75 studies
ValueUnitEndpointRouteSpeciesSource
0.5%-oralratUnifiedCodex:SCCNFP:beta.noael_studies
2mg/kg bw/day-oral-UnifiedCodex:SCCNFP:beta.noael_studies
2mg/kg bw/day-oral-UnifiedCodex:SCCNFP:beta.noael_studies
2mg/kg bw/day-oral-UnifiedCodex:SCCNFP:beta.noael_studies
2mg/kg bw/day-oral-UnifiedCodex:SCCNFP:beta.noael_studies
7mg/kg bw/day---UnifiedCodex:SCCNFP:beta.noael_studies
20mg/kg bw/day---UnifiedCodex:SCCNFP:beta.noael_studies
TLH4A6LV1WUNIIFDA UNII substance identifier--openFDA substances
TLH4A6LV1WUNIIFDA UNII substance identifier--openFDA substances
TLH4A6LV1WUNIIFDA UNII substance identifier--openFDA substances
TLH4A6LV1WUNIIFDA UNII substance identifier--openFDA substances
2mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.5%NOAELoralratSCCNFP_vision_codex
=0.5%NOAELoralratSCCNFP_vision_codex
=0.5%NOAELoralratSCCNFP_vision_codex
=0.5%NOAELoralratSCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAELoral-SCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAELoral-SCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAELoral-SCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=2mg/kg bw/dayNOAELoral-SCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=7mg/kg bw/dayNOAEL-rabbitSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL--SCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL--SCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL--SCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL--SCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCNFP_vision_codex
=300mg/kgNOAELdermalratSCCNFP_vision_codex
=300mg/kgNOAELdermalratSCCNFP_vision_codex

Showing 50 of 75 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL LAWSONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Hydroxy-1,4-naphthoquinone?

2-Hydroxy-1,4-naphthoquinone has 75 NOAEL studies in the database. The lowest reported value is 0.5 % via oral in rat. Source: UnifiedCodex:SCCNFP:beta.noael_studies.

What regulatory lists include 2-Hydroxy-1,4-naphthoquinone?

2-Hydroxy-1,4-naphthoquinone appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Canada; pharmaceutical. Source: EPA CPDat.

Is 2-Hydroxy-1,4-naphthoquinone used in cosmetics?

Yes, 2-Hydroxy-1,4-naphthoquinone is also indexed as a cosmetic ingredient under the name Lawsone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxy-1,4-naphthoquinone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Hydroxy-1,4-naphthoquinone used outside industrial chemicals?

2-Hydroxy-1,4-naphthoquinone also appears in cosmetics, pharmaceutical, food safety databases.