What is the NOAEL for Sodium picramate?
Sodium picramate has 9 NOAEL studies in the database. The lowest reported value is 0.493 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium picramate
Also known as: Phenol, 2-amino-4,6-dinitro-, monosodium salt, EC No.: 212-603-8, 2-Amino-4,6-dinitrophenol monosodium salt, EINECS 212-603-8, UNII-4988SZV57R (+1 more)
CAS 831-52-7
Sodium picramate (CAS 831-52-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Sodium picramate is classified GHS Danger (H301, H302, H312, H317, H332, H412, H360F, H203) in the chemicals database but is restricted in EU cosmetics at max 0.6%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
11 fields
Name
Sodium picramate
CAS Number
831-52-7
DTXSID
DTXSID2061193
Molecular Formula
C6H5N3O5.Na
InChI Key
UENNEPPWFZYINW-UHFFFAOYSA-M
Synonyms
Phenol, 2-amino-4,6-dinitro-, monosodium saltEC No.: 212-603-82-Amino-4,6-dinitrophenol monosodium saltEINECS 212-603-8UNII-4988SZV57R212-603-8
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.493 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 4988SZV57R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4988SZV57R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4988SZV57R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4988SZV57R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | mg/kg bw/day | NOAEL | dermal | Rabbit | ECHA |
| =100 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =100 | mg/kg bw/day | NOEL | dermal | Rat | ECHA |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 2-amino-4,6-dinitrophenoxide | 212-603-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.6%
Category
Colorant
Frequently Asked Questions
What regulatory lists include Sodium picramate?
Sodium picramate appears on 1 regulatory/inventory list including Europe; Personal care - hair coloring. Source: EPA CPDat.
Is Sodium picramate used in cosmetics?
Yes, Sodium picramate is also indexed as a cosmetic ingredient under the name Sodium Picramate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium picramate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium picramate have different safety status in cosmetics vs industrial chemicals?
Sodium picramate is classified GHS Danger (H301, H302, H312, H317, H332, H412, H360F, H203) in the chemicals database but is restricted in EU cosmetics at max 0.6%.
Is Sodium picramate used outside industrial chemicals?
Sodium picramate also appears in cosmetics databases.