Is Sodium Picramate safe in cosmetics?
Sodium Picramate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Sodium Picramate
Also known as: Phenol, 2-amino-4,6-dinitro-, monosodium salt, EC No.: 212-603-8, 2-Amino-4,6-dinitrophenol monosodium salt, EINECS 212-603-8, UNII-4988SZV57R (+1 more)
INCI: SODIUM PICRAMATE
Sodium Picramate (CAS 831-52-7) is a cosmetic cosmetic ingredient functioning as Hair dye (oxidative and non-oxidative formulations). Reported NOAEL =20 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted, max 0.6%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 831-52-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Picramate is classified GHS Danger (H301, H302, H312, H317, H332, H412, H360F, H203) in the chemicals database but is restricted in EU cosmetics at max 0.6%.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Hair dye (oxidative and non-oxidative formulations)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium 2-amino-4,6-dinitrophenolate
InChIKey
UENNEPPWFZYINW-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.6%
US US Status
permitted
US Notes
Permitted for use in hair dyes; not approved for use near eyes
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Picramate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Sodium Picramate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =20 mg/kg bw/day | oral | Rat | short-term | ECHA |
| NOAEL | =50 mg/kg bw/day | dermal | Rabbit | subchronic | ECHA |
| NOAEL | =100 mg/kg bw/day | dermal | Rat | reproduction developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | restricted | 0.1% | Hair dyes only |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "831-52-7", "ingredient_class": "direct_dye", "chemical_class": "nitro", "color_result_on_hair": "Orange-red", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-10", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration_depth…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Picramate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Picramate by CAS number or substance name.
Studies
3
Lowest NOAEL
20 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ECHA
Known Synonyms
Phenol, 2-amino-4,6-dinitro-, monosodium salt
EC No.: 212-603-8
2-Amino-4,6-dinitrophenol monosodium salt
EINECS 212-603-8
UNII-4988SZV57R
212-603-8
Chemical Function
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Sodium Picramate allowed in the EU?
Sodium Picramate EU regulatory status: restricted. Maximum allowed concentration: 0.6%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Picramate do in cosmetics?
Sodium Picramate functions as: Hair dye (oxidative and non-oxidative formulations). It is classified as a cosmetic ingredient in our database. CAS number: 831-52-7.
What is the NOAEL for Sodium Picramate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Picramate is =20 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Is Sodium Picramate used outside cosmetics?
Sodium Picramate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Picramate have different safety status in cosmetics vs industrial chemicals?
Sodium Picramate is classified GHS Danger (H301, H302, H312, H317, H332, H412, H360F, H203) in the chemicals database but is restricted in EU cosmetics at max 0.6%.
Compliance Tools
Check Sodium Picramate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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