What is the NOAEL for 2-Amino-4-hydroxyethylaminoanisole?
2-Amino-4-hydroxyethylaminoanisole has 49 NOAEL studies in the database. The lowest reported value is 30 mg/kg bw in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
Cosmetic Ingredient
2-Amino-4-hydroxyethylaminoanisole
Also known as: EINECS 280-733-2, UNII-0NK0KYZ30R
CAS 83763-47-7
2-Amino-4-hydroxyethylaminoanisole (CAS 83763-47-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for 2-Amino-4-Hydroxyethylaminoanisole →
Cross-Vertical Regulatory Divergence
2-Amino-4-hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
49
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
2-Amino-4-hydroxyethylaminoanisole
CAS Number
83763-47-7
DTXSID
DTXSID50232617
Molecular Formula
C9H14N2O2
InChI Key
SBUMIGFDXJIPLE-UHFFFAOYSA-N
Monoisotopic Mass
182.105528
Synonyms
EINECS 280-733-2UNII-0NK0KYZ30R
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 49 of 49 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 30 | mg/kg bw | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 150 | mg/kg bw | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 150 | mg/kg bw | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 150 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 150 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0NK0KYZ30R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NK0KYZ30R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NK0KYZ30R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NK0KYZ30R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.23 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.23 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.23 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.23 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =30 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw | NOAEL | - | rat | SCCS_vision_codex |
| =150 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =0.23 | mg/kg | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =15 | mg/kg | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =15 | mg/kg | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | mg/kg bw | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | mg/kg bw | repeated dose toxicity | dermal | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | mg/kg bw/day | repeated dose toxicity | dermal | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 49 of 49 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1382/10 | 13 October 2009 | safe | 1.5% | sensitisation not excluded |
| SCCP/1148/08 | 24 June 2008 | safe | 1.5% | sensitisation not excluded; updated safety assessment |
| SCCP/0908/05 | 28 March 2006 | insufficient data | - | genotoxicity data required; further testing needed |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
1.5%
Category
Colorant
Frequently Asked Questions
What regulatory lists include 2-Amino-4-hydroxyethylaminoanisole?
2-Amino-4-hydroxyethylaminoanisole appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is 2-Amino-4-hydroxyethylaminoanisole used in cosmetics?
Yes, 2-Amino-4-hydroxyethylaminoanisole is also indexed as a cosmetic ingredient under the name 2-Amino-4-Hydroxyethylaminoanisole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Amino-4-hydroxyethylaminoanisole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Amino-4-hydroxyethylaminoanisole have different safety status in cosmetics vs industrial chemicals?
2-Amino-4-hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).
Is 2-Amino-4-hydroxyethylaminoanisole used outside industrial chemicals?
2-Amino-4-hydroxyethylaminoanisole also appears in cosmetics databases.