NOAEL Data Cosmetic Ingredient

2-Amino-4-hydroxyethylaminoanisole

Also known as: EINECS 280-733-2, UNII-0NK0KYZ30R

CAS 83763-47-7

2-Amino-4-hydroxyethylaminoanisole (CAS 83763-47-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for 2-Amino-4-Hydroxyethylaminoanisole →

Cross-Vertical Regulatory Divergence

2-Amino-4-hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields

Name

2-Amino-4-hydroxyethylaminoanisole

CAS Number

83763-47-7

Molecular Formula

C9H14N2O2

InChI Key

SBUMIGFDXJIPLE-UHFFFAOYSA-N

Monoisotopic Mass

182.105528

Synonyms

EINECS 280-733-2UNII-0NK0KYZ30R

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies

Value	Unit	Endpoint	Route	Species	Source
30	mg/kg bw	-	-	rat	Regulatory source
30	mg/kg bw/day	-	-	rat	Regulatory source
150	mg/kg bw	-	-	rat	Regulatory source
150	mg/kg bw/day	-	-	rat	Regulatory source
150	mg/kg bw/day	-	-	human	Regulatory source
0NK0KYZ30R	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.23	mg/kg	NOAEL	oral	rat	SCCS Opinion
=15	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=15	mg/kg	NOAEL	oral	rat	SCCS Opinion
=15	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=30	mg/kg bw	NOAEL	-	rat	SCCS Opinion
=30	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=150	mg/kg bw	NOAEL	-	rat	SCCS Opinion
=150	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=0.23	mg/kg	dermal absorption	oral	rat	Regulatory source
=15	mg/kg	dermal absorption	oral	rat	Regulatory source
15	mg/kg bw	repeated dose toxicity	oral	rat	Regulatory source
15	mg/kg bw	repeated dose toxicity	dermal	rat	Regulatory source
15	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
15	mg/kg bw/day	repeated dose toxicity	dermal	rat	Regulatory source

Showing 20 of 20 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 4 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1382/10	13 October 2009	safe	1.5%	sensitisation not excluded
SCCP/1148/08	24 June 2008	safe	1.5%	sensitisation not excluded; updated safety assessment
SCCP/0908/05	28 March 2006	insufficient data	-	genotoxicity data required; further testing needed
SCCP/0958/05	2006-03-28	Based on the information provided, a margin of safety of 65 has been calculated suggesting that 2-amino-4-hydroxyethylamino-anisole and its sulfate is not safe for use as a hair dye and should not be present in hair dyes or other cosmetic products.	-	Margin of safety of only 65 calculated; percutaneous absorption value is critical to the MOS; a skin penetration test conforming to current Notes of Guidance would be required before any re-evaluation.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.5%

Frequently Asked Questions

What is the NOAEL for 2-Amino-4-hydroxyethylaminoanisole?

2-Amino-4-hydroxyethylaminoanisole has 20 NOAEL studies in the database. The lowest reported value is 0.23 mg/kg via oral in rat. Source: Regulatory source.

What regulatory lists include 2-Amino-4-hydroxyethylaminoanisole?

2-Amino-4-hydroxyethylaminoanisole appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.

Is 2-Amino-4-hydroxyethylaminoanisole used in cosmetics?

Yes, 2-Amino-4-hydroxyethylaminoanisole is also indexed as a cosmetic ingredient under the name 2-Amino-4-Hydroxyethylaminoanisole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Amino-4-hydroxyethylaminoanisole come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Amino-4-hydroxyethylaminoanisole have different safety status in cosmetics vs industrial chemicals?

2-Amino-4-hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).

Is 2-Amino-4-hydroxyethylaminoanisole used outside industrial chemicals?

2-Amino-4-hydroxyethylaminoanisole also appears in cosmetics databases.