Moderate Cosmetic Ingredient Sensitization Data

2-Amino-4-Hydroxyethylaminoanisole

INCI: 2-AMINO-4-HYDROXYETHYLAMINOANISOLE

CAS Number
83763-47-7
Function
Hair dyeing — oxidative coupling agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 1.5%
🇺🇸 US Status permitted
US Notes CIR concluded safe in current practices of use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for 2-Amino-4-Hydroxyethylaminoanisole based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG; ESSCA

Expert Verdict

Secondary amine that must not be used with nitrosating substances; nitrosamine content must be <50 ppb. Restricted under ASEAN Annex III and NZ Cosmetic Group Standard Schedule 5.

⚠️
Concern Level: High

Frequently Asked Questions

Is 2-Amino-4-Hydroxyethylaminoanisole safe in cosmetics?

Secondary amine that must not be used with nitrosating substances; nitrosamine content must be <50 ppb. Restricted under ASEAN Annex III and NZ Cosmetic Group Standard Schedule 5. The EU classifies 2-Amino-4-Hydroxyethylaminoanisole as "prohibited". Safety rating: MODERATE.

Is 2-Amino-4-Hydroxyethylaminoanisole allowed in the EU?

2-Amino-4-Hydroxyethylaminoanisole EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Amino-4-Hydroxyethylaminoanisole do in cosmetics?

2-Amino-4-Hydroxyethylaminoanisole functions as: Hair dyeing — oxidative coupling agent. It is classified as a cosmetic ingredient in our database. CAS number: 83763-47-7.

What is the Margin of Safety for 2-Amino-4-Hydroxyethylaminoanisole?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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