Also known as: EINECS 280-733-2, UNII-0NK0KYZ30R
INCI: 2-AMINO-4-HYDROXYETHYLAMINOANISOLE
2-Amino-4-Hydroxyethylaminoanisole (CAS 83763-47-7) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative coupling agent. Reported NOAEL =0.23 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 83763-47-7 →
2-Amino-4-Hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-4-Hydroxyethylaminoanisole.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2-Amino-4-Hydroxyethylaminoanisole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.23 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.23 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.23 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.23 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Contact sensitization data for 2-Amino-4-Hydroxyethylaminoanisole based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | restricted | 1.5 | oxidative hair dye products |
| GCC | restricted | 1.5 | Oxidative hair dye only |
| KR | prohibited | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.02% | - | - | SCCP/0043 |
| measured | 0.18% | - | - | SCCP/0043 |
| measured | 0.57% | - | - | SCCP/0043 |
| measured | 0.75% | - | - | SCCP/0043 |
| measured | 0.128% | - | - | SCCP/0043 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2-Amino-4-Hydroxyethylaminoanisole.
Public NOAEL study rows linked to 2-Amino-4-Hydroxyethylaminoanisole by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.02% | - | - |
| 0.18% | - | - |
| 0.57% | - | - |
| 0.75% | - | - |
| 0.128% | - | - |
2-Amino-4-Hydroxyethylaminoanisole has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Amino-4-Hydroxyethylaminoanisole EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
2-Amino-4-Hydroxyethylaminoanisole functions as: Hair dyeing — oxidative coupling agent. It is classified as a cosmetic ingredient in our database. CAS number: 83763-47-7.
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-4-Hydroxyethylaminoanisole is =0.23 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2-Amino-4-Hydroxyethylaminoanisole also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Amino-4-Hydroxyethylaminoanisole is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302).
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