NOAEL Data REACH Registered Cosmetic Ingredient

Diethyl phthalate

Also known as: 1,2-Benzenedicarboxylic acid, diethyl ester, 4-09-00-03172, BRN 1912500, Diethyl o-phenylenediacetate, Di-n-ethyl phthalate (+12 more)

CAS 84-66-2

Diethyl phthalate (CAS 84-66-2) is a chemical substance. Key regulatory status: REACH registered, 54 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Diethyl Phthalate (DEP) →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
54
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields
Name
Diethyl phthalate
CAS Number
84-66-2
DTXSID
DTXSID7021780
Molecular Formula
C12H14O4
InChI Key
FLKPEMZONWLCSK-UHFFFAOYSA-N
Monoisotopic Mass
222.089209
Synonyms
1,2-Benzenedicarboxylic acid, diethyl ester4-09-00-03172BRN 1912500Diethyl o-phenylenediacetateDi-n-ethyl phthalateEINECS 201-550-6NCI-C60048RCRA waste number U088Diethylester kyseliny ftalovePhthalsaeurediaethylesterUNII-UF064M00AF1,2-Diethyl phthalate

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA5 mg/m³-5N
ACGIHTWA5 mg/m³ [1996]-5N
CAL/OSHATWA5 mg/m³-5N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragranceSolventFilm formerPlasticizerDeodorizerSoftener and conditionerProcessing aids not otherwise specifiedLubricating agentViscosity modifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 54 records
ListKeywordSource
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goodsDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
detected; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
detected; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - body adhesiveDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - children's art and toys - modeling clay; detectedSpringerPublished Articles
Other direct contact consumer goodsEnvironmental Health PerspectivesPublished Articles
detected; Other direct contact consumer goods; Toys and children's productsReproductive ToxicologyPublished Articles
IFRA TransparencyIFRAIFRA
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
childrenVermont Department of HealthState of Vermont
nondetect; Toys and children's productsState of Washington Department of EcologyState of Washington
childrenOregon Health AuthorityState of Oregon
air; detected; emissions; Europe; Road vehiclesDanish Environmental Protection AgencyDanish EPA
children; WA Children's Safe Product Act (4/2020)State of Washington Department of EcologyState of Washington
Arts and crafts/Office supplies - children's art and toys; nondetect; Toys and children's productsState of Washington Department of EcologyState of Washington
detected; Personal care - child specificState of Washington Department of EcologyState of Washington
detected; Personal care - child specificState of Washington Department of EcologyState of Washington
children; detected; Personal care - make-up and relatedState of Washington Department of EcologyState of Washington
children; detected; Personal care - fragranceState of Washington Department of EcologyState of Washington
nondetect; Toys and children's productsState of Washington Department of EcologyState of Washington
nondetect; Toys and children's productsState of Washington Department of EcologyState of Washington
children; detected; Packaging (non-food contact)State of Washington Department of EcologyState of Washington

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=0.25%-oralratUnifiedCodex:SCCNFP:beta.noael_studies
0.25%---UnifiedCodex:SCCNFP:beta.noael_studies
>2.5%---UnifiedCodex:SCCNFP:beta.noael_studies
<2.5%---UnifiedCodex:SCCNFP:beta.noael_studies
=5%-oralratUnifiedCodex:SCCNFP:beta.noael_studies
5%---UnifiedCodex:SCCNFP:beta.noael_studies
150mg /kg bw-oralratUnifiedCodex:SCCNFP:beta.noael_studies
<500mg/kg---UnifiedCodex:SCCNFP:beta.noael_studies
1600mg/kg---UnifiedCodex:SCCNFP:beta.noael_studies
296.57ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
296.6ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
121.04ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
>1555.68ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
>200ug/mLCV70Dermal-NTP_ICE_skin_sensitization
600ug/mLCV75Dermal-NTP_ICE_skin_sensitization
42.5uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=10.56mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
0.2%Depletion CysDermal-NTP_ICE_skin_sensitization
0.8%Depletion CysDermal-NTP_ICE_skin_sensitization
-0.7%Depletion LysDermal-NTP_ICE_skin_sensitization
2.5%Depletion LysDermal-NTP_ICE_skin_sensitization
0.4%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
1.4%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
59.97uMEC1.5Dermal-NTP_ICE_skin_sensitization
183.54uMEC1.5Dermal-NTP_ICE_skin_sensitization
<516.41uMEC1.5Dermal-NTP_ICE_skin_sensitization
582.7uMEC1.5Dermal-NTP_ICE_skin_sensitization
913.7uMEC1.5Dermal-NTP_ICE_skin_sensitization
1180.53uMEC1.5Dermal-NTP_ICE_skin_sensitization
>2000uMEC1.5Dermal-NTP_ICE_skin_sensitization
UF064M00AFUNIIFDA UNII substance identifier--openFDA substances
UF064M00AFUNIIFDA UNII substance identifier--openFDA substances
UF064M00AFUNIIFDA UNII substance identifier--openFDA substances
UF064M00AFUNIIFDA UNII substance identifier--openFDA substances
0.19fractionFu-HumanNTP_ICE_adme_parameters
>1285uMIC50Dermal-NTP_ICE_skin_sensitization
1879.05uMIC50Dermal-NTP_ICE_skin_sensitization
1.047ratioImaxDermal-NTP_ICE_skin_sensitization
1.049ratioImaxDermal-NTP_ICE_skin_sensitization
1.07ratioImaxDermal-NTP_ICE_skin_sensitization
1.081ratioImaxDermal-NTP_ICE_skin_sensitization
1.088ratioImaxDermal-NTP_ICE_skin_sensitization
1.1ratioImaxDermal-NTP_ICE_skin_sensitization
1.113ratioImaxDermal-NTP_ICE_skin_sensitization
1.132ratioImaxDermal-NTP_ICE_skin_sensitization
1.138ratioImaxDermal-NTP_ICE_skin_sensitization
1.192ratioImaxDermal-NTP_ICE_skin_sensitization
1.2ratioImaxDermal-NTP_ICE_skin_sensitization
1.327ratioImaxDermal-NTP_ICE_skin_sensitization
1.391ratioImaxDermal-NTP_ICE_skin_sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredDiethyl phthalate201-550-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. Additional information becoming available on the adverse health effects of DEP. b. Information to indicate that the levels of use of DEP in products in Australia are higher than the estimated levels used in this report. c. Additional sources of public exposure to DEP giving rise to similar levels as those found in the cosmetics scenario in this report. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIETHYL PHTHALATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Diethyl phthalate?

Diethyl phthalate has 100 NOAEL studies in the database. The lowest reported value is -0.7 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Diethyl phthalate?

Diethyl phthalate appears on 33 regulatory/inventory lists including detected; Europe; Toys and children's products, detected; Europe; Other direct contact consumer goods, air; detected; emissions; Europe; Vehicle - car interior, and 30 more. Source: EPA CPDat.

What are the occupational exposure limits for Diethyl phthalate?

Occupational exposure limits for Diethyl phthalate are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Diethyl phthalate used in cosmetics?

Yes, Diethyl phthalate is also indexed as a cosmetic ingredient under the name Diethyl Phthalate (DEP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diethyl phthalate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Diethyl phthalate used outside industrial chemicals?

Diethyl phthalate also appears in cosmetics, pharmaceutical, cannabis databases.