What is the NOAEL for Diethyl phthalate?
Diethyl phthalate has 100 NOAEL studies in the database. The lowest reported value is -0.7 % via Dermal. Source: NTP_ICE_skin_sensitization.
Also known as: 1,2-Benzenedicarboxylic acid, diethyl ester, 4-09-00-03172, BRN 1912500, Diethyl o-phenylenediacetate, Di-n-ethyl phthalate (+12 more)
CAS 84-66-2
Diethyl phthalate (CAS 84-66-2) is a chemical substance. Key regulatory status: REACH registered, 54 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
CAS, identifiers, formula, and alternate names for the matched substance record.
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| ACGIH | TWA | 5 mg/m³ [1996] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - body adhesive | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected | Springer | Published Articles |
| Other direct contact consumer goods | Environmental Health Perspectives | Published Articles |
| detected; Other direct contact consumer goods; Toys and children's products | Reproductive Toxicology | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| children | Vermont Department of Health | State of Vermont |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children | Oregon Health Authority | State of Oregon |
| air; detected; emissions; Europe; Road vehicles | Danish Environmental Protection Agency | Danish EPA |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| Arts and crafts/Office supplies - children's art and toys; nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Personal care - child specific | State of Washington Department of Ecology | State of Washington |
| detected; Personal care - child specific | State of Washington Department of Ecology | State of Washington |
| children; detected; Personal care - make-up and related | State of Washington Department of Ecology | State of Washington |
| children; detected; Personal care - fragrance | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children; detected; Packaging (non-food contact) | State of Washington Department of Ecology | State of Washington |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.25 | % | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 0.25 | % | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| >2.5 | % | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| <2.5 | % | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| =5 | % | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 5 | % | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 150 | mg /kg bw | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| <500 | mg/kg | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 1600 | mg/kg | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 296.57 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 296.6 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 121.04 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >1555.68 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 600 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 42.5 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =10.56 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.4 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.4 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 59.97 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 183.54 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| <516.41 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 582.7 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 913.7 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 1180.53 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| UF064M00AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UF064M00AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UF064M00AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UF064M00AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.19 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >1285 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1879.05 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.047 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.049 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.07 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.081 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.088 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.113 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.132 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.138 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.192 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.2 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.327 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.391 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl phthalate | 201-550-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Diethyl phthalate has 100 NOAEL studies in the database. The lowest reported value is -0.7 % via Dermal. Source: NTP_ICE_skin_sensitization.
Diethyl phthalate appears on 33 regulatory/inventory lists including detected; Europe; Toys and children's products, detected; Europe; Other direct contact consumer goods, air; detected; emissions; Europe; Vehicle - car interior, and 30 more. Source: EPA CPDat.
Occupational exposure limits for Diethyl phthalate are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diethyl phthalate is also indexed as a cosmetic ingredient under the name Diethyl Phthalate (DEP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Diethyl phthalate also appears in cosmetics, pharmaceutical, cannabis databases.