Diethyl Phthalate (DEP)
INCI: DIETHYL PHTHALATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diethyl Phthalate (DEP). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 other | dermal | code:3543 | dermal | REACH |
| NOAEL | 0.1 other | oral | rat | oral | REACH |
| NOAEL | 75 other | dermal | rat | dermal | REACH |
| LOAEL | 2 other | other | dog | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Regulatory compliance maintained; however, subject to class-wide phthalate consumer perception risk, potential endocrine disruption concerns, and retailer-driven reformulation pressure despite adequate margin of safety.
Regulatory Flags
Frequently Asked Questions
Is Diethyl Phthalate (DEP) safe in cosmetics?
Regulatory compliance maintained; however, subject to class-wide phthalate consumer perception risk, potential endocrine disruption concerns, and retailer-driven reformulation pressure despite adequate margin of safety. The EU classifies Diethyl Phthalate (DEP) as "permitted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Diethyl Phthalate (DEP) allowed in the EU?
Diethyl Phthalate (DEP) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Phthalate (DEP) do in cosmetics?
Diethyl Phthalate (DEP) functions as: Solvent, denaturant, fragrance fixative. It is classified as a cosmetic ingredient in our database. CAS number: 84-66-2.
What is the Margin of Safety for Diethyl Phthalate (DEP)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Phthalate (DEP)?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Phthalate (DEP) is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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