Is Diethyl Phthalate (DEP) safe in cosmetics?
Diethyl Phthalate (DEP) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Diethyl Phthalate (DEP)
INCI: DIETHYL PHTHALATE
Diethyl Phthalate (DEP) (CAS 84-66-2) is a cosmetic cosmetic ingredient functioning as Solvent, denaturant, fragrance fixative. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 84-66-2 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, denaturant, fragrance fixative
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
diethyl benzene-1,2-dicarboxylate
InChIKey
FLKPEMZONWLCSK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; FDA has not banned DEP in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Phthalate (DEP).
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Diethyl Phthalate (DEP).
Regulatory Flags
fragrance-component
ifra_fragrance
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIETHYL PHTHALATE
ChEMBL ID
CHEMBL388558
Max Phase
-1
Frequently Asked Questions
Is Diethyl Phthalate (DEP) allowed in the EU?
Diethyl Phthalate (DEP) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Phthalate (DEP) do in cosmetics?
Diethyl Phthalate (DEP) functions as: Solvent, denaturant, fragrance fixative. It is classified as a cosmetic ingredient in our database. CAS number: 84-66-2.
Is Diethyl Phthalate (DEP) used outside cosmetics?
Diethyl Phthalate (DEP) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethyl Phthalate (DEP) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is Diethyl Phthalate (DEP) in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diethyl Phthalate (DEP) in your formulation.