NOAEL Data Cosmetic Ingredient

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine

Also known as: EINECS 281-856-4, UNII-3X0E669O5S

CAS 84041-77-0

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine (CAS 84041-77-0) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE →

SOURCE NOAEL studies
NOAEL studies
37
SOURCE Chemical inventory jurisdictions
Regulatory lists
4
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine
CAS Number
84041-77-0
Molecular Formula
C10H15N3O4
InChI Key
HWQZRURILVPDGN-UHFFFAOYSA-N
Monoisotopic Mass
241.106256
Synonyms
EINECS 281-856-4UNII-3X0E669O5S

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies
ValueUnitEndpointRouteSpeciesSource
5mg/kg bw/day--ratRegulatory source
50mg/kg bw/day--ratRegulatory source
240mg/kg/day---Regulatory source
240mg/kg bw/d---Regulatory source
1200mg/kg/day--humanRegulatory source
3X0E669O5SUNIIFDA UNII substance identifier--openFDA substances
80mg/kg bw/dayLOAELoralratCOSMOS DB
=0.017mg/kg bw/dNOAELoralratSCCS Opinion
=0.029mg/kg bw/dNOAELoralratSCCS Opinion
=5mg/kg bw/dayNOAEL-ratSCCS Opinion
=5mg/kg bw/dayNOAELdermal-SCCNFP Opinion
=50mg/kg bw/dayNOAEL-ratSCCS Opinion
=50mg/kg bw/dayNOAELdermal-SCCNFP Opinion
=100mg/kg bw/dayNOAELoralratSCCS Opinion
=100mg/kg bw/dayNOAELdermalratSCCNFP Opinion
=120mg/kg bw/dNOAELoralratSCCS Opinion
=240mg/kg/dayNOAEL--SCCS Opinion
=240mg/kg bw/dNOAELoralratSCCS Opinion
=720mg/kg bw/dayNOAEL-mouseSCCS Opinion
=1000mg/kgNOAELoralratSCCS Opinion
=1000mg/kg bw/dayNOAELdermalratSCCNFP Opinion
=1200mg/kg/dayNOAEL-humanSCCS Opinion
=0.017mg/kg bw/ddermal absorptionoralratRegulatory source
=0.029mg/kg bw/ddermal absorptionoralratRegulatory source
100mg/kg bw/daydermal absorptiondermalratRegulatory source
=120mg/kg bw/ddermal absorptionoralratRegulatory source
=240mg/kg bw/ddermal absorptionoralratRegulatory source
1000mg/kg bw/daydermal absorptiondermalratRegulatory source
1200mg/kg/daydermal absorptiondermalratRegulatory source
100mg/kg bw/daydevelopmental toxicityoralratRegulatory source
1000mg/kgdevelopmental toxicityoralratRegulatory source
1000mg/kgdevelopmental toxicity-ratRegulatory source
240mg/kg/daygenotoxicity--Regulatory source
240mg/kg bw/dgenotoxicity--Regulatory source
240mg/kg/dayirritation--Regulatory source
240mg/kg bw/dayirritation--Regulatory source
720mg/kg bw/dayirritation-mouseRegulatory source

Showing 37 of 37 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 4 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1572/1616 September 2016safe with restrictions1.0% oxidative / 1.5% non-oxidativesecondary amine; nitrosamine content <50ppb
SCCS/1471/1226-27 June 2012not safe-gene mutation potential unresolved; further testing required
SCCS/1394/1023 March 2010not safe-genotoxicity concerns unresolved
SCCS/1228/092010-03-23The SCCS is of the opinion that a conclusion on the gene mutation potential of N,N'-bis-(2-hydroxyethyl)-2-nitro-p-phenylenediamine cannot be drawn without further testing.-Conclusion on gene mutation potential cannot be drawn without further testing. Secondary amine prone to nitrosation; nitrosamine content should be <50 ppb; should not be used in presence of nitrosating agents.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Hair Dyes
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine?

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine has 37 NOAEL studies in the database. The lowest reported value is 0.017 mg/kg bw/d via oral in rat. Source: SCCS Opinion.

What regulatory lists include N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine?

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.

Is N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine used in cosmetics?

Yes, N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine is also indexed as a cosmetic ingredient under the name N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine used outside industrial chemicals?

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine also appears in cosmetics databases.