Good Cosmetic Ingredient NOAEL Data

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE

CAS Number
84041-77-0
Function
Hair Dyeing
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status allowed
US Notes Allowed โ€” falls under the coal tar hair dye exemption (FD\&C Act ยง601(a)); requires caution statement and patch test directions on label

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 80 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is listed in the EU CosIng database with functions: Hair Dyeing It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment

Frequently Asked Questions

Is N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE safe in cosmetics?

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is listed in the EU CosIng database with functions: Hair Dyeing It is permitted in the EU without specific restrictions. The EU classifies N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE as "Permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE allowed in the EU?

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE do in cosmetics?

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 84041-77-0.

What is the NOAEL for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE?

The NOAEL (No Observed Adverse Effect Level) for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is 80 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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