Also known as: EINECS 281-856-4, UNII-3X0E669O5S
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE (CAS 84041-77-0) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =5 mg/kg bw/day (SCCNFP Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84041-77-0 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
10 study endpoints found for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =5 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =5 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =5 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =50 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =50 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =50 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =50 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =100 mg/kg bw/day | dermal | rat | dermal absorption | SCCNFP Opinion |
| NOAEL | =100 mg/kg bw/day | dermal | rat | dermal absorption | SCCNFP Opinion |
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.22% | - | - | SCCS/0096 |
| measured | 0.22% | - | - | SCCS/0196 |
Preliminary editorial summary for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.22% | - | - |
| 0.22% | - | - |
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed. 10 toxicological study endpoint(s) are available in our database.
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 84041-77-0.
The NOAEL (No Observed Adverse Effect Level) for N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is =5 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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