NOAEL Data REACH Registered Cosmetic Ingredient

Alpha-Arbutin

Also known as: UNII-72VUP07IT5

CAS 84380-01-8

Alpha-Arbutin (CAS 84380-01-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for Alpha-Arbutin →

SOURCE NOAEL studies
NOAEL studies
31
SOURCE Chemical inventory jurisdictions
Regulatory lists
2
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
Alpha-Arbutin
CAS Number
84380-01-8
Molecular Formula
C12H16O7
InChI Key
BJRNKVDFDLYUGJ-ZIQFBCGOSA-N
Monoisotopic Mass
272.089603
Synonyms
UNII-72VUP07IT5

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records
AntioxidantSoftener and conditionerBleaching agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies
ValueUnitEndpointRouteSpeciesSource
2%---Regulatory source
9----Regulatory source
=15mg/kg/day--ratRegulatory source
=20mg/kg/day-oralratRegulatory source
20mg/kg bw/day-dermal-Regulatory source
=74mg/kg/day-dermalratRegulatory source
100mg/kg bw/day-dermal-Regulatory source
344---ratRegulatory source
72VUP07IT5UNIIFDA UNII substance identifier--openFDA substances
=2%NOAEL--SCCS Opinion
=3.3-NOAELoralguinea pigSCCS Opinion
=9-NOAEL--SCCS Opinion
=15mg/kg/dayNOAELoralratSCCS Opinion
=15mg/kg bwNOAELoral-SCCS Opinion
=15mg/kg bw/dNOAEL--SCCS Opinion
=20mg/kg/dayNOAELoralratSCCS Opinion
=20mg/kg bw/dayNOAELdermal-SCCS Opinion
=20mg/kg bwNOAELoral-SCCS Opinion
=20%NOAELdermalguinea pigSCCS Opinion
=20mg/kg bw/dNOAEL--SCCS Opinion
=25mg/kg/dayNOAELoralratSCCS Opinion
=29-NOAELoral-SCCS Opinion
=56-NOAELdermal-SCCS Opinion
=74mg/kg/dayNOAELoralratSCCS Opinion
=75mg/kg/dayNOAELoralratSCCS Opinion
=100mg/kg bw/dayNOAELdermal-SCCS Opinion
=150mg/kg/dayNOAEL-ratSCCS Opinion
>250mg/kg bwNOAELoralratSCCS Opinion
=344-NOAEL-ratSCCS Opinion
=1000mg/kg bw/dayNOAELoralratSCCS Opinion
=1550-NOAELoralratSCCS Opinion

Showing 31 of 31 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered4-hydroxyphenyl-alpha-D-glucopyranoside440-470-8ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1552/1527 May 2015safe with restrictions2% face cream; 0.5% body lotionHydroquinone release potential; limited data on other product types; precursor to updated SCCS/1642/22

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
2% face / 0.5% body
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL226495
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Alpha-Arbutin?

Alpha-Arbutin has 31 NOAEL studies in the database. The lowest reported value is 2 %. Source: Regulatory source.

What regulatory lists include Alpha-Arbutin?

Alpha-Arbutin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.

Is Alpha-Arbutin used in cosmetics?

Yes, Alpha-Arbutin is also indexed as a cosmetic ingredient under the name Alpha-Arbutin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alpha-Arbutin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Alpha-Arbutin used outside industrial chemicals?

Alpha-Arbutin also appears in cosmetics, pharmaceutical databases.