What is the NOAEL for 2,6-Dihydroxy-3,4-dimethylpyridine?
2,6-Dihydroxy-3,4-dimethylpyridine has 15 NOAEL studies in the database. The lowest reported value is 3VDO3A5MTW UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,6-Dihydroxy-3,4-dimethylpyridine
Also known as: 2(1H)-Pyridinone, 6-hydroxy-4,5-dimethyl-, 2(1H)-Pyridinone, 6-hydroxy-3,4-dimethyl-, 6-Hydroxy-4,5-dimethyl-2(1H)-pyridinone, 6-hydroxy-3,4-dimethyl-2-pyridone, EC No.: 283-141-2 (+2 more)
CAS 84540-47-6
2,6-Dihydroxy-3,4-dimethylpyridine (CAS 84540-47-6) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.
View cosmetic safety profile for 2,6-Dihydroxy-3,4-Dimethylpyridine →
SOURCE
NOAEL studies
NOAEL studies
15
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
2,6-Dihydroxy-3,4-dimethylpyridine
CAS Number
84540-47-6
Molecular Formula
C7H9NO2
InChI Key
KIEGFAYDOKCBOK-UHFFFAOYSA-N
Monoisotopic Mass
139.063329
Synonyms
2(1H)-Pyridinone, 6-hydroxy-4,5-dimethyl-2(1H)-Pyridinone, 6-hydroxy-3,4-dimethyl-6-Hydroxy-4,5-dimethyl-2(1H)-pyridinone6-hydroxy-3,4-dimethyl-2-pyridoneEC No.: 283-141-2EINECS 283-141-2UNII-3VDO3A5MTW
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3VDO3A5MTW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 160 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.017 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| 80 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =80 | mg/kg | NOAEL | oral | human | SCCS Opinion |
| =100 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =100 | mg/kg | NOAEL | oral | rabbit | SCCS Opinion |
| =1000 | mg/kg | NOAEL | oral | - | SCCS Opinion |
| =0.017 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| =80 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 80 | mg/kg | dermal absorption | oral | rabbit | Regulatory source |
| 100 | mg/kg | dermal absorption | oral | rabbit | Regulatory source |
| 80 | mg/kg | developmental toxicity | oral | human | Regulatory source |
| 100 | mg/kg bw | genotoxicity | - | rat | Regulatory source |
| 1000 | mg/kg | repeated dose toxicity | oral | - | Regulatory source |
Showing 15 of 15 studies
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1002/06 | 19 December 2006 | safe | 1.0% | sensitisation not excluded |
| SCCP/1034/06 | 2006-12-19 | Based on the information provided, the SCCP is of the opinion that the use of 2,6-Dihydroxy-3,4-dimethylpyridine itself as an oxidative hair dye substance at a maximum concentration of 1.0% in the finished cosmetic product (after mixing with hydrogen peroxide) does not pose a risk to the health of the consumer, apart from its sensitising potential. | 1.0% | Sensitising potential (considered a possible skin sensitiser); not mutagenic in vivo, but genotoxicity/mutagenicity studies on finished hair dye formulations should be undertaken per SCCNFP/SCCP Notes of Guidance. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.0%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3086520
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,6-Dihydroxy-3,4-dimethylpyridine?
2,6-Dihydroxy-3,4-dimethylpyridine appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Is 2,6-Dihydroxy-3,4-dimethylpyridine used in cosmetics?
Yes, 2,6-Dihydroxy-3,4-dimethylpyridine is also indexed as a cosmetic ingredient under the name 2,6-Dihydroxy-3,4-Dimethylpyridine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6-Dihydroxy-3,4-dimethylpyridine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,6-Dihydroxy-3,4-dimethylpyridine used outside industrial chemicals?
2,6-Dihydroxy-3,4-dimethylpyridine also appears in cosmetics, pharmaceutical databases.